+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

F-fucoidan from Saccharina japonica is a novel inducer of galectin-9 and exhibits anti-allergic activity

F-fucoidan from Saccharina japonica is a novel inducer of galectin-9 and exhibits anti-allergic activity

Journal of Clinical Biochemistry and Nutrition 59(1): 25-30

Fucoidan is a sulfated polysaccharide from brown sea algae. In the present study, it was demonstrated that oral administration of F-fucoidan from Saccharina japonica possessed anti-allergic effects using the passive cutaneous anaphylaxis reaction, but not by intraperitoneal administration. The inhibitory mechanism was dependent on galectin-9, which belongs to a soluble lectin family that recognizes β-galactoside and prevents IgE binding to mast cells. The anti-allergy properties of F-fucoidan were cancelled by an intravenous dose of anti-galectin-9 antibody or lactose, which bind competitively with galectin-9 before the passive cutaneous anaphylaxis reaction. F-fucoidan increased the expression level of galectin-9 mRNA in intestinal epithelial cells and serum galectin-9 levels. Oral treatment with F-fucoidan suppressed allergic symptoms through the induction of galectin-9. This is the first report that F-fucoidan can induce the secretion of galectin-9.

(PDF emailed within 0-6 h: $19.90)

Accession: 057851854

Download citation: RISBibTeXText

PMID: 27499575

DOI: 10.3164/jcbn.15-144

Related references

Anti-inflammatory effect of low molecular weight fucoidan from Saccharina japonica on atherosclerosis in apoE-knockout mice. International Journal of Biological Macromolecules 118(Pt A): 365-374, 2018

Structural, antioxidant, and emulsifying activities of fucoidan from Saccharina japonica using pressurized liquid extraction. Carbohydrate Polymers 153: 518-525, 2018

Fucoidan from the sea cucumber Acaudina molpadioides exhibits anti-adipogenic activity by modulating the Wnt/β-catenin pathway and down-regulating the SREBP-1c expression. Food and Function 5(7): 1547-1555, 2015

Anti-inflammatory activity of edible brown alga Saccharina japonica and its constituents pheophorbide a and pheophytin a in LPS-stimulated RAW 264.7 macrophage cells. Food and Chemical Toxicology 55: 541-548, 2013

Structural features and anticancer activity in vitro of fucoidan derivatives from brown alga Saccharina cichorioides. Carbohydrate Polymers 157: 1503-1510, 2018

Fucoidan supplementation improves exercise performance and exhibits anti-fatigue action in mice. Nutrients 7(1): 239-252, 2015

Δ-lactam derivative from thermophilic soil fungus exhibits in vitro anti-allergic activity. Natural Product Research 26(23): 2168-2175, 2013

Meliae cortex extract exhibits anti-allergic activity through the inhibition of Syk kinase in mast cells. Toxicology and Applied Pharmacology 220(3): 227-234, 2007

Genetic Map Construction and Quantitative Trait Locus (QTL) Detection of Six Economic Traits Using an F2 Population of the Hybrid from Saccharina longissima and Saccharina japonica. Plos One 10(5): E0128588, 2016

Synergistic anti-inflammatory effects of Laminaria japonica fucoidan and Cistanche tubulosa extract. Laboratory Animal Research 28(2): 91-97, 2012

Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4. Journal of Bioscience and Bioengineering 121(1): 36-42, 2016

Galectin-7 exhibits pro-apoptotic activity in epithelial cells. FASEB Journal 14(4): A554, March 15, 2000

The structure property and endothelial protective activity of fucoidan from Laminaria japonica. International Journal of Biological Macromolecules 105(Pt 2): 1421-1429, 2017

HH1-1, a novel Galectin-3 inhibitor, exerts anti-pancreatic cancer activity by blocking Galectin-3/EGFR/AKT/FOXO3 signaling pathway. Carbohydrate Polymers 204: 111-123, 2018

Antithrombotic activity of oral administered low molecular weight fucoidan from Laminaria Japonica. Thrombosis Research 144: 46-52, 2017