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Failure of a Single Varicella Vaccination to Protect Children with Cancer from Life-Threatening Breakthrough Varicella

Kelley, J.; Tristram, D.; Yamada, M.; Grose, C.

Pediatric Infectious Disease Journal 34(9): 1027-1029

2015

ISSN/ISBN: 1532-0987
PMID: 25955833
DOI: 10.1097/inf.0000000000000737
Accession: 057862090
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We report 2 children with life-threatening breakthrough varicella. Both had received 1 varicella vaccination before onset of cancer. Despite treatment with intravenous acyclovir, 1 child died of disseminated varicella. Because similar fatal cases have been reported, high-risk immunocompromised children with 1 varicella vaccination may warrant the same varicella prophylaxis as immunocompromised children who have never been vaccinated.

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