+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

First complete genome sequence of European turkey coronavirus suggests complex recombination history related with US turkey and guinea fowl coronaviruses



First complete genome sequence of European turkey coronavirus suggests complex recombination history related with US turkey and guinea fowl coronaviruses



Journal of General Virology 97(1): 110-120



A full-length genome sequence of 27,739  nt was determined for the only known European turkey coronavirus (TCoV) isolate. In general, the order, number and size of ORFs were consistent with other gammacoronaviruses. Three points of recombination were predicted, one towards the end of 1a, a second in 1b just upstream of S and a third in 3b. Phylogenetic analysis of the four regions defined by these three points supported the previous notion that European and American viruses do indeed have different evolutionary pathways. Very close relationships were revealed between the European TCoV and the European guinea fowl coronavirus in all regions except one, and both were shown to be closely related to the European infectious bronchitis virus (IBV) Italy 2005. None of these regions of sequence grouped European and American TCoVs. The region of sequence containing the S gene was unique in grouping all turkey and guinea fowl coronaviruses together, separating them from IBVs. Interestingly the French guinea fowl virus was more closely related to the North American viruses. These data demonstrate that European turkey and guinea fowl coronaviruses share a common genetic backbone (most likely an ancestor of IBV Italy 2005) and suggest that this recombined in two separate events with different, yet related, unknown avian coronaviruses, acquiring their S-3a genes. The data also showed that the North American viruses do not share a common backbone with European turkey and guinea fowl viruses; however, they do share similar S-3a genes with guinea fowl virus.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 057880452

Download citation: RISBibTeXText

PMID: 26585962


Related references

Complete nucleotide sequence of polyprotein gene 1 and genome organization of turkey coronavirus. Virus Research 136(1-2): 43-49, 2008

Genetic characterization of astroviruses detected in guinea fowl (Numida meleagris) reveals a distinct genotype and suggests cross-species transmission between turkey and guinea fowl. Archives of Virology 157(7): 1329-1337, 2012

Expressed sequence tags for the chicken genome from a normalized, ten-day-old white leghorn whole embryo cDNA library. 2. Comparative DNA sequence analysis of guinea fowl, quail, and turkey genomes. Poultry Science 80(9): 1263-1272, 2001

Turkey coronavirus is more closely related to avian infectious bronchitis virus than to mammalian coronaviruses: a review. Avian Pathology 29(3): 207-212, 2000

Multiplex real-time reverse transcription-polymerase chain reaction for the detection of three viruses associated with poult enteritis complex: turkey astrovirus, turkey coronavirus, and turkey reovirus. Avian Diseases 49(1): 86-91, 2005

Complete genomic sequence of turkey coronavirus. Virus Research 135(2): 237-246, 2008

Full genome sequence of guinea fowl coronavirus associated with fulminating disease. Virus Genes 50(3): 514-517, 2015

Manipulation of the coronavirus genome using targeted RNA recombination with interspecies chimeric coronaviruses. Methods in Molecular Biology 454: 229-236, 2008

Detection of turkey enteric coronavirus by enzyme-linked immunosorbent assay and differentiation from other coronaviruses. American Journal of Veterinary Research 50(2): 226-231, 1989

Specific real-time reverse transcription-polymerase chain reaction for detection and quantitation of turkey coronavirus RNA in tissues and feces from turkeys infected with turkey coronavirus. Journal of Virological Methods 163(2): 452-458, 2010

Evolutionary history of the closely related group 2 coronaviruses: porcine hemagglutinating encephalomyelitis virus, bovine coronavirus, and human coronavirus OC43. Journal of Virology 80(14): 7270-7274, 2006

Complete genome sequence analysis of the Malacosoma neustria nucleopolyhedrovirus from Turkey. Virus Genes 54(5): 706-718, 2018

The first complete genome sequence of a non-chicken aviadenovirus, proposed to be turkey adenovirus 1. Virus Research 153(2): 226-233, 2010

The complete sequence and analysis of the turkey (Meleagris gallopavo) mitochondrial genome. Poultry Science 85: 118-118, 2006

Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event. Journal of Virology 79(3): 1595-1604, 2005