+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Five Sequential Evaluations of Renal Histology in a Patient with Light Chain Deposition Disease

Five Sequential Evaluations of Renal Histology in a Patient with Light Chain Deposition Disease

Internal Medicine 55(20): 2993-2999

A 58-year-old man was referred to our institution for an evaluation of nephrotic range proteinuria. Renal biopsy showed a marked expansion of the mesangial matrix and thickening of glomerular basement membrane (GBM) in periodic acid-silver methenamine (PAM). Immunofluorescence (IF) revealed strong staining for the monoclonal kappa light chain. EM demonstrated massive subendothelial and mesangial dense deposits. As a result, light chain deposition disease (LCDD) was diagnosed. Melphalan and prednisolone (MP) therapy was started, which was continued for 10 years with minimal complications. Serial evaluations of renal histology revealed the resolution of nodular lesions and the glomeruli became nearly normal. MP therapy can therefore be an effective therapeutic option for LCDD if it is continued over the long term.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 057883265

Download citation: RISBibTeXText

PMID: 27746438

DOI: 10.2169/internalmedicine.55.6213

Related references

Renal disease and patient survival in light chain deposition disease. Clinical Nephrology 43(5): 281-287, 1995

Monoclonal immunoglobulin deposition disease: light chain and light and heavy chain deposition diseases and their relation to light chain amyloidosis. Clinical features, immunopathology, and molecular analysis. Annals of Internal Medicine 112(6): 455-464, 1990

Hematologic response and stabilization of renal function in a patient with light chain deposition disease after lenalidomide treatment: a novel therapeutic approach?. Clinical Lymphoma Myeloma and Leukemia 14(5): E179, 2014

Urinary findings in renal light chain-derived amyloidosis and light chain deposition disease. Clinical Lymphoma and Myeloma 9(3): 234-238, 2009

Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease. Hematology/Oncology Clinics of North America 6(2): 323-346, 1992

Stable long-term renal function in a patient with κ-light chain renal tubular crystalline deposition. Clinical Nephrology 83(3): 189-195, 2015

Light chain deposition disease of the liver without renal involvement in a patient with multiple myeloma related to liver failure and rapid fatal outcome. Digestive Diseases and Sciences 47(4): 730-734, 2002

Metachronous development of nonamyloidogenic [lambda] light chain deposition disease and IgG heavy chain amyloidosis in the same patient. American Journal of Surgical Pathology 27(11): 1477-1482, 2003

Light chain deposition disease (nodular glomerulopathy, kappa light chain deposition disease): a case report. Ultrastructural Pathology 18(1-2): 119-126, 1994

Serum free light-chain assay for nonsecretory multiple myeloma with light chain cast nephropathy and light chain deposition disease. Japanese Journal of Clinical Hematology 51(4): 270-274, 2010

Sequential autologous peripheral blood stem cell transplantation and kidney transplantaion of light chain deposition disease. Nephrology, Dialysis, Transplantation 22(4): 1268-1269, 2006

Development of systemic lambda-light chain amyloidosis in a patient with gamma-heavy chain deposition disease during long-term follow-up. Nephrology Dialysis Transplantation 20(2): 434-437, 2005

Light chain deposition disease as a cause of renal failure. Casopis Lekaru Ceskych 137(23): 721-724, 1998

The renal pathology in light chain deposition disease. Giornale Italiano di Nefrologia 22(Suppl. 33): S53, 2005

Light chain deposition disease after renal transplantation. American Journal of Kidney Diseases 52(3): 621-625, 2008