EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate, cetirizine hydrochloride in combined pharmaceutical dosage form: a new era in novel drug delivery for pediatrics and geriatrics


Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate, cetirizine hydrochloride in combined pharmaceutical dosage form: a new era in novel drug delivery for pediatrics and geriatrics



Journal of Drug Delivery 2015: 640529



ISSN/ISBN: 2090-3014

PMID: 25810924

DOI: 10.1155/2015/640529

The objective of the present study was to prepare the fast disintegrating tablet of Salbutamol Sulphate, Cetirizine Hydrochloride in combined tablet dosage form for respiratory disorders such as bronchitis, asthma, and coughing for pediatrics and geriatrics. The tablets were prepared by direct compression technique. Superdisintegrant such as Sodium Starch Glycolate was optimized as 4% on the basis of least disintegration time. Different binders such as MCC and PVP K-30 were optimized along with optimized superdisintegrant concentration. 1% MCC was selected as optimum binder concentration on the basis of least disintegration time. The tablets were evaluated for hardness, friability, weight variation, wetting time, disintegration time, and drug content uniformity. Optimized formulation was further evaluated by in vitro dissolution test, drug-excipient compatibility, and accelerated stability study. Percent weight variation and content uniformity were within the acceptable limit. The friability was less than 1%. The wetting time and disintegration time were practically good for all formulations. FTIR studies and accelerated stability study showed that there was no interaction between the drug and excipients. It was concluded that, by employing commonly available pharmaceutical excipients such as superdisintegrants, hydrophilic and swellable excipients and proper filler, a fast disintegrating tablet of Salbutamol Sulphate, Cetirizine Hydrochloride in combined tablet dosage form, were formulated successfully with desired characteristics.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057895184

Download citation: RISBibTeXText

Related references

Formulation Development and Evaluation of Fast Disintegrating Tablet of Cetirizine Hydrochloride: a Novel Drug Delivery for Pediatrics and Geriatrics. Journal of Pharmaceutics 2014: 808167, 2014

Formulation development and evaluation of fast disintegrating tablets of salbutamol sulphate for respiratory disorders. Isrn Pharmaceutics 2013: 674507, 2013

A Comparative Study of Different Proportions of Superdisintegrants: Formulation and Evaluation of Orally Disintegrating Tablets of Salbutamol Sulphate. Turkish Journal of Pharmaceutical Sciences 14(1): 40-48, 2017

A pharmaceutical study on lornoxicam fast disintegrating tablets: formulation and in vitro and in vivo evaluation. Drug Delivery and Translational Research 7(3): 450-459, 2017

Progresses and Challenges of Fast Dissolving/Disintegrating Dosage Forms in Manufacturing, Formulation Screening, Preclinical Testing and Drug Delivery. Recent Patents on Drug Delivery and Formulation 14(1): 3-4, 2020

Combined Effect of Synthetic and Natural Polymers in Preparation of Cetirizine Hydrochloride Oral Disintegrating Tablets: Optimization by Central Composite Design. Journal of Pharmaceutics 2017: 8305976, 2017

Formulation Development and evaluation of fast disintegrating tablets of Lamotrigine using liqui-solid technique. International Journal of Pharmaceutical Investigation 4(4): 207-214, 2014

RP-HPLC and Spectrophotometric Estimation of Ambroxol Hydrochloride and Cetirizine Hydrochloride in Combined Dosage Form. Indian Journal of Pharmaceutical Sciences 70(5): 603-608, 2008

Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets. Journal of Drug Delivery 2014: 827035, 2014

Development and evaluation of cetirizine HCl taste-masked oral disintegrating tablets. Aaps Pharmscitech 12(1): 141-151, 2011

Formulation and evaluation of bioadhesive buccal drug delivery of tizanidine hydrochloride tablets. Aaps Pharmscitech 10(2): 530-539, 2009

Formulation and evaluation of chondroitin sulphate tablets of aceclofenac for colon targeted drug delivery. Iranian Journal of Pharmaceutical Research: Ijpr 11(2): 465-479, 2012

Formulation and Evaluation of Fast-Disintegrating Sublingual Tablets of Atropine Sulfate: the Effect of Tablet Dimensions and Drug Load on Tablet Characteristics. Aaps Pharmscitech 18(5): 1624-1633, 2017

Formulation development and characterization of fast disintegrating tablets of Nimesulide. Stamford Journal of Pharmaceutical Sciences 4(2): 25-28, 2012

Formulation design of an oral, fast-disintegrating dosage form containing taste-masked particles of famotidine. Chemical and Pharmaceutical Bulletin 56(7): 946-950, 2008