+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Frailty as a Predictor of Alzheimer Disease, Vascular Dementia, and All Dementia Among Community-Dwelling Older People: A Systematic Review and Meta-Analysis



Frailty as a Predictor of Alzheimer Disease, Vascular Dementia, and All Dementia Among Community-Dwelling Older People: A Systematic Review and Meta-Analysis



Journal of the American Medical Directors Association 17(10): 881-888



To perform a systematic search of the literature for currently available evidence on frailty as a predictor of dementia and to conduct a meta-analysis to synthesize the pooled risk estimates among community-dwelling older people. A systematic review and meta-analysis. Embase, MEDLINE, CINAHL Plus, PsycINFO, and the Cochrane Library from 2000 to January 2016, and reference lists of relevant articles. Any studies that prospectively examined the incident risks of dementia with frailty among community-dwelling older people without language restriction. Of 2565 studies identified through the systematic review, 7 studies were included in this review. Of these, 4 studies reported hazard ratios (HR) of incident dementia for physical frailty defined by Cardiovascular Health Study criteria and were included in a meta-analysis. Frailty was a significant predictor of incident Alzheimer disease (4 studies: pooled HR = 1.28, 95% confidence interval (95% CI) = 1.00-1.63, P = .05), vascular dementia (2 studies: pooled HR 2.70, 95% CI 1.40-5.23, P = .003), and all dementia (3 studies: pooled HR 1.33, 95% CI 1.07-1.67, P = .01). Heterogeneity across the studies was low to modest (I(2) = 0%-51%). A random-effects meta-regression analysis showed that the female proportion of the cohort primarily mediated the association of frailty with Alzheimer disease (female proportion coefficient = 0.04, 95%CI = 0.01-0.08, P = .01). This systematic review and meta-analysis suggests that frailty was a significant predictor of Alzheimer disease, vascular dementia, and all dementia among community-dwelling older people. Frail women may have a higher risk of incident Alzheimer disease than frail men.

(PDF emailed within 0-6 h: $19.90)

Accession: 057898161

Download citation: RISBibTeXText

PMID: 27324809

DOI: 10.1016/j.jamda.2016.05.013


Related references

Frailty as a predictor of disabilities among community-dwelling older people: a systematic review and meta-analysis. Disability and Rehabilitation 39(19): 1897-1908, 2016

Frailty as a predictor of hospitalisation among community-dwelling older people: a systematic review and meta-analysis. Journal of Epidemiology and Community Health 70(7): 722-729, 2018

Frailty as a predictor of fractures among community-dwelling older people: A systematic review and meta-analysis. Bone 90: 116-122, 2017

Frailty as a Predictor of Future Falls Among Community-Dwelling Older People: A Systematic Review and Meta-Analysis. Journal of the American Medical Directors Association 16(12): 1027-1033, 2016

Frailty as a Predictor of Emergency Department Utilization among Community-Dwelling Older People: A Systematic Review and Meta-Analysis. Journal of the American Medical Directors Association 2018, 2018

Frailty as a Predictor of Nursing Home Placement Among Community-Dwelling Older Adults: A Systematic Review and Meta-analysis. Journal of Geriatric Physical Therapy 41(1): 42-48, 2016

Transitions between frailty states among community-dwelling older people: A systematic review and meta-analysis. Ageing Research Reviews 2019, 2019

Association between frailty and quality of life among community-dwelling older people: a systematic review and meta-analysis. Journal of Epidemiology and Community Health 70(7): 716-721, 2018

Prevalence and Risk Factors for Frailty among Community-Dwelling Older People in China: A Systematic Review and Meta-Analysis. Journal of Nutrition, Health and Aging 23(5): 442-450, 2019

Health promotion interventions for community-dwelling older people with mild or pre-frailty: a systematic review and meta-analysis. Bmc Geriatrics 17(1): 157, 2018

Quality of life is substantially worse for community-dwelling older people living with frailty: systematic review and meta-analysis. Quality of Life Research 2019, 2019

Sarcopenia as a predictor of all-cause mortality among community-dwelling older people: A systematic review and meta-analysis. Maturitas 103: 16-22, 2018

Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies. British Journal of Psychiatry 202(5): 329-335, 2013

Effectiveness of exercise programs to reduce falls in older people with dementia living in the community: a systematic review and meta-analysis. Clinical Interventions in Aging 10: 421-434, 2015

Cognitive Frailty Predicts Incident Dementia among Community-Dwelling Older People. Journal of Clinical Medicine 7(9), 2018