+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China

Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China

Cell Host and Microbe 20(6): 810-821

Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific. H5N6 viruses constitute at least 34 distinct genotypes derived from various evolutionary pathways. Notably, genotype G1.2 virus, with internal genes from the chicken H9N2/H7N9 gene pool, was responsible for at least five human H5N6 infections. Our findings highlight H5N6 AIVs as potential threats to public health and agriculture.

(PDF emailed within 0-6 h: $19.90)

Accession: 057927187

Download citation: RISBibTeXText

PMID: 27916476

DOI: 10.1016/j.chom.2016.10.022

Related references

Genesis and Dissemination of Highly Pathogenic H5N6 Avian Influenza Viruses. Journal of Virology 91(5), 2016

Novel Reassortant Avian Influenza A(H5N6) Viruses in Humans, Guangdong, China, 2015. Emerging Infectious Diseases 22(8): 1507-1509, 2018

Novel reassortant highly pathogenic H5N6 avian influenza viruses in poultry in China. Infection, Genetics and Evolution 31: 64-67, 2015

New Reassortant H5N6 Highly Pathogenic Avian Influenza Viruses in Southern China, 2014. Frontiers in Microbiology 7: 754, 2016

Molecular Evolution and Emergence of H5N6 Avian Influenza Virus in Central China. Journal of Virology 91(12), 2017

Novel reassortment of avian influenza A(H7N9) virus with subtype H6N6 and H5N6 viruses circulating in Guangdong Province, China. Journal of Infection 75(2): 179-182, 2017

Isolation of H5N6, H7N9 and H9N2 avian influenza A viruses from air sampled at live poultry markets in China, 2014 and 2015. Euro Surveillance 21(35), 2017

Genetic diversity and dissemination pathways of highly pathogenic H5N6 avian influenza viruses from birds in Southwestern China along the East Asian-Australian migration flyway. Journal of Infection 76(4): 418-422, 2017

Genetic and biological characterization of three poultry-origin H5N6 avian influenza viruses with all internal genes from genotype S H9N2 viruses. Archives of Virology 163(4): 947-960, 2018

Novel Highly Pathogenic Avian Influenza A(H5N6) Viruses in the Netherlands. Emerging Infectious Diseases 24(7): 1393, 2018

Pathogenicity and transmissibility of three avian influenza A (H5N6) viruses isolated from wild birds. Journal of Infection 76(3): 286-294, 2018

Identification of two novel avian influenza a (H5N6) viruses in wild birds, Shanghai, in 2016. Veterinary Microbiology 208: 53-57, 2018

Two novel reassortants of avian influenza A (H5N6) virus in China. Journal of General Virology 96(Pt 5): 975-981, 2015

Multiple novel H5N6 highly pathogenic avian influenza viruses, South Korea, 2016. Infection, Genetics and Evolution 51: 21-23, 2017

Identification of Two novel reassortant avian influenza a (H5N6) viruses in whooper swans in Korea, 2016. Virology Journal 14(1): 60, 2017