+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Genetic deletion of melanin-concentrating hormone neurons impairs hippocampal short-term synaptic plasticity and hippocampal-dependent forms of short-term memory



Genetic deletion of melanin-concentrating hormone neurons impairs hippocampal short-term synaptic plasticity and hippocampal-dependent forms of short-term memory



Hippocampus 25(11): 1361-1373



The cognitive role of melanin-concentrating hormone (MCH) neurons, a neuronal population located in the mammalian postero-lateral hypothalamus sending projections to all cortical areas, remains poorly understood. Mainly activated during paradoxical sleep (PS), MCH neurons have been implicated in sleep regulation. The genetic deletion of the only known MCH receptor in rodent leads to an impairment of hippocampal dependent forms of memory and to an alteration of hippocampal long-term synaptic plasticity. By using MCH/ataxin3 mice, a genetic model characterized by a selective deletion of MCH neurons in the adult, we investigated the role of MCH neurons in hippocampal synaptic plasticity and hippocampal-dependent forms of memory. MCH/ataxin3 mice exhibited a deficit in the early part of both long-term potentiation and depression in the CA1 area of the hippocampus. Post-tetanic potentiation (PTP) was diminished while synaptic depression induced by repetitive stimulation was enhanced suggesting an alteration of pre-synaptic forms of short-term plasticity in these mice. Behaviorally, MCH/ataxin3 mice spent more time and showed a higher level of hesitation as compared to their controls in performing a short-term memory T-maze task, displayed retardation in acquiring a reference memory task in a Morris water maze, and showed a habituation deficit in an open field task. Deletion of MCH neurons could thus alter spatial short-term memory by impairing short-term plasticity in the hippocampus. Altogether, these findings could provide a cellular mechanism by which PS may facilitate memory encoding. Via MCH neuron activation, PS could prepare the day's learning by increasing and modulating short-term synaptic plasticity in the hippocampus.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057929837

Download citation: RISBibTeXText

PMID: 25808129

DOI: 10.1002/hipo.22442


Related references

Satb2 Ablation Impairs Hippocampus-Based Long-Term Spatial Memory and Short-Term Working Memory and Immediate Early Genes (IEGs)-Mediated Hippocampal Synaptic Plasticity. Molecular Neurobiology 2017:, 2017

Selective modification of short-term hippocampal synaptic plasticity and impaired memory extinction in mice with a congenitally reduced hippocampal commissure. Journal of Neuroscience 22(18): 8277-8286, 2002

Selective modification of short term hippocampal synaptic plasticity and impaired contextual fear memory extinction in mice with a congenitally reduced hippocampal commissure. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 778 12, 2002

Okadaic acid attenuates short-term and long-term synaptic plasticity of hippocampal dentate gyrus neurons in rats. Neurobiology of Learning and Memory 158: 24-31, 2019

JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1. European Journal of Neuroscience 25(2): 391-396, 2007

Kidins220/ARMS is a novel modulator of short-term synaptic plasticity in hippocampal GABAergic neurons. Plos one 7(4): E35785, 2012

MicroRNA132 modulates short-term synaptic plasticity but not basal release probability in hippocampal neurons. Plos one 5(12): E15182, 2010

Enhancement of postsynaptic L-type calcium channel activity impairs short-term synaptic facilitation in hippocampal neurons. Society for Neuroscience Abstracts 27(1): 537, 2001

Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America 113(4): 1062-1067, 2016

Impaired hippocampal memory and short-term synaptic plasticity in the dentate gyrus in mice lacking 5-HT1A receptors. Society for Neuroscience Abstracts 25(1-2): 1464, 1999

Differences in multiple forms of short-term plasticity between excitatory and inhibitory hippocampal neurons in culture. Synapse 50(1): 41-52, 2003

Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Impairs Synaptic Plasticity and Hippocampal-Dependent Memory. Journal of Neuroscience 36(8): 2348-2354, 2016

RGS2 determines short-term synaptic plasticity in hippocampal neurons by regulating Gi/o-mediated inhibition of presynaptic Ca2+ channels. Neuron 51(5): 575-586, 2006

Constitutive Inactivation of the PRRT2 Gene Alters Short-Term Synaptic Plasticity and Promotes Network Hyperexcitability in Hippocampal Neurons. Cerebral Cortex 29(5): 2010-2033, 2019

Differentiation between dorsal and ventral CA1 hippocampal region in both short-term and long-term synaptic plasticity. European Journal of Neuroscience 12(Suppl. 11): 388, 2000