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Genetics in myeloma: genetic technologies and their application to screening approaches in myeloma

Genetics in myeloma: genetic technologies and their application to screening approaches in myeloma

British Medical Bulletin 113(1): 15-30

ISSN/ISBN: 0007-1420

PMID: 25662536

DOI: 10.1093/bmb/ldu041

Despite advances in the treatment of multiple myeloma (MM), it remains an incurable malignant disease. Myeloma genetics is intrinsically complex, but it offers an opportunity to categorize the disease and apply a personalized medicine approach. Research into the genetics of myeloma is moving at a fast pace and is highlighting areas and patient cohorts likely to benefit from specific treatment. Targeting residual disease is likely to be crucial to improved clinical outcome. Patients in clinical trials are more likely to receive genetic diagnosis than non-trial patients, for whom access is ad hoc and dependent upon regional commissioning arrangements. Relating genetics to potential treatment pathways will become crucial for improved myeloma outcomes. Universal access to standardized genetic testing will facilitate modern personalized treatments.

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Accession: 057932766

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