+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hepatic infarction in a pregnant woman with antiphospholipid syndrome and triple antibody positivity: A case report focusing on catastrophic antiphospholipid syndrome

Hepatic infarction in a pregnant woman with antiphospholipid syndrome and triple antibody positivity: A case report focusing on catastrophic antiphospholipid syndrome

Obstetrics and Gynecology Science 59(5): 397-402

Pregnant women with antiphospholipid syndrome (APS) carry a high risk of arterial or venous thrombosis. Such thrombotic conditions occur more frequently in patients with triple positivity to antiphospholipid antibodies or with high antibody titers. Hepatic infarction is a rare complication in pregnant women with APS, and it sometimes mimics HELLP syndrome. This report describes a preeclamptic pregnant woman with APS who had high titers of three antiphospholipid antibodies. She experienced severe epigastric pain with elevated liver enzymes; in addition, she had tachycardia and tachypnea. The clinical findings suggested hepatic infarction and pulmonary thromboembolism, a partial manifestation of catastrophic APS. Therefore, she underwent emergent cesarean section at 25+2 weeks of gestation. After the delivery, her laboratory test indicated HELLP-like features, and computed tomography confirmed hepatic infarction and pulmonary micro-thromboembolism. Here, we report a case of a partial manifestation of catastrophic APS in a pregnant woman with triple antibody positivity, including a brief literature review.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 057980472

Download citation: RISBibTeXText

PMID: 27668204

DOI: 10.5468/ogs.2016.59.5.397

Related references

Catastrophic antiphospholipid antibody syndrome in systemic lupus erythematosus: an autopsy case report of a young woman. Internal Medicine 39(10): 856-859, 2000

Acute myocardial infarction with variable clinical manifestations: probable catastrophic primary antiphospholipid antibody syndrome: a case report. Journal of Cardiology 46(4): 155-160, 2005

Acute myocardial infarction due to antiphospholipid antibody syndrome in a young pregnant woman. Journal of Cardiology Cases 4(1): E8, 2011

A case of probable catastrophic antiphospholipid syndrome with multi-organ failure presenting as a transient increase of antiphospholipid antibody levels. Nihon Rinsho Men'eki Gakkai Kaishi 37(3): 183-188, 2014

Progression of antiphospholipid antibody syndrome to catastrophic antiphospholipid antibody syndrome acutely with cessation of antithrombotic therapy. Internal Medicine Journal 42(5): 585-591, 2012

Successful treatment of catastrophic antiphospholipid syndrome in a pregnant woman. Clinical and Experimental Rheumatology 17(2): 261, 1999

The catastrophic antiphospholipid antibody syndrome: case report and review of the literature. Der Nervenarzt 86(2): 205-209, 2015

Eculizumab in a pregnant patient with laboratory onset of catastrophic antiphospholipid syndrome: A case report. Medicine 97(40): E12584, 2018

Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity. A European multicentre retrospective study. Thrombosis and Haemostasis 112(4): 727-735, 2014

Catastrophic antiphospholipid syndrome (CAS): a rare manifestation of the antiphospholipid antibody syndrome. Clinical and Experimental Rheumatology 11(6): 653-657, 1993

Catastrophic cerebral antiphospholipid syndrome presenting as cerebral infarction with haemorrhagic transformation after sudden withdrawal of warfarin in a patient with primary antiphospholipid syndrome. Bmj Case Reports 2010:, 2010

Therapeutic plasma exchange in the treatment of catastrophic antiphospholipid antibody syndrome A case report. Transfusion 39(10 Suppl. ): 9S, 1999

Catastrophic antiphospholipid antibody syndrome in a young woman in the postpartum period. Tennessee Medicine 103(10): 35-6 39, 2011

Hepatic infarction during pregnancy in catastrophic antiphospholipid syndrome. Journal of Gastroenterology and Hepatology 22(10): 1695-1696, 2007

Severe renal hemorrhage in a pregnant woman complicated with antiphospholipid syndrome: a case report. Advances in Urology 2011: 791094, 2011