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Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response


Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response



Journal of Biological Chemistry 291(15): 7788-7795



ISSN/ISBN: 0021-9258

PMID: 26907689

DOI: 10.1074/jbc.r116.714980

The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeastSaccharomyces cerevisiaewere isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.

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Accession: 057985423

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