+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hidden Wounds? Inflammatory Links Between Childhood Trauma and Psychopathology



Hidden Wounds? Inflammatory Links Between Childhood Trauma and Psychopathology



Annual Review of Psychology 68: 517-544



Childhood trauma is a key risk factor for psychopathology. However, little is known about how exposure to childhood trauma is translated into biological risk for psychopathology. Observational human studies and experimental animal models suggest that childhood exposure to stress can trigger an enduring systemic inflammatory response not unlike the bodily response to physical injury. In turn, these "hidden wounds" of childhood trauma can affect brain development, key behavioral domains (e.g., cognition, positive valence systems, negative valence systems), reactivity to subsequent stressors, and, ultimately, risk for psychopathology. Further research is needed to better characterize the inflammatory links between childhood trauma and psychopathology. Detecting and healing these hidden wounds may help prevent and treat psychopathology emerging after childhood trauma.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057985958

Download citation: RISBibTeXText

PMID: 27575032

DOI: 10.1146/annurev-psych-010416-044208


Related references

The hidden wounds of childhood trauma. European Journal of Psychotraumatology 8(Sup5): 137584, 2017

Inflammatory Links Between Childhood Trauma And Affective Disorders. Journal of the American Academy of Child & Adolescent Psychiatry 55(10): S313-S314, 2016

Psychopathology, childhood sexual abuse and other childhood adversities: relative links to subsequent suicidal behaviour in the US. Psychological Medicine 31(6): 965-977, 2001

When one childhood meets another - maternal childhood trauma and offspring child psychopathology: A systematic review. Clinical Child Psychology and Psychiatry 23(3): 483-500, 2018

The Role of Caregiver Psychopathology in the Treatment of Childhood Trauma with Trauma-Focused Cognitive Behavioral Therapy: A Systematic Review. Clinical Child and Family Psychology Review 22(3): 273-289, 2019

Association between maternal childhood trauma and offspring childhood psychopathology: mediation analysis from the ALSPAC cohort. British Journal of Psychiatry 211(3): 144-150, 2017

Associations of childhood trauma, trauma in adulthood and previous-year stress with psychopathology in patients with major depression and borderline personality disorder. Child Abuse and Neglect 35(8): 647-654, 2011

A Review of: The Trauma Spectrum: Hidden Wounds and Human Resilience. Journal of Sex & Marital Therapy 34(1): 90-91, 2007

A Review of: The Trauma Spectrum: Hidden Wounds and Human Resilience. Clinical Child Psychology and Psychiatry 12(1): 148-149, 2007

Exposure to potentially traumatic events in early childhood: differential links to emergent psychopathology. Journal of Child Psychology and Psychiatry and Allied Disciplines 51(10): 1132-1140, 2010

Childhood trauma and psychosis: a case-control and case-sibling comparison across different levels of genetic liability, psychopathology, and type of trauma. American Journal of Psychiatry 168(12): 1286-1294, 2011

Childhood sexual trauma, cannabis use and psychosis: statistically controlling for pre-trauma psychosis and psychopathology. Social Psychiatry and Psychiatric Epidemiology 48(6): 853-861, 2013

Psychopathology and sexual trauma in childhood and adulthood. Journal of Traumatic Stress 16(1): 35-38, 2003

Research links childhood trauma to schizophrenia. 2012

Emotion and empiricism: research on childhood trauma and adult psychopathology. Journal of Personality Disorders 11(1): 1-3, 1997