+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

High-throughput platforms for the screening of new therapeutic targets for neurodegenerative diseases



High-throughput platforms for the screening of new therapeutic targets for neurodegenerative diseases



Drug Discovery Today 21(9): 1355-1366



Despite the recent progress in the understanding of neurodegenerative disorders, a lack of solid fundamental knowledge on the etiology of many of the major neurodegenerative diseases has made it difficult to obtain effective therapies to treat these conditions. Scientists have been looking to carry out more-human-relevant studies, with strong statistical power, to overcome the limitations of preclinical animal models that have contributed to the failure of numerous therapeutics in clinical trials. Here, we identify currently existing platforms to mimic central nervous system tissues, healthy and diseased, mainly focusing on cell-based platforms and discussing their strengths and limitations in the context of the high-throughput screening of new therapeutic targets and drugs.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 057995631

Download citation: RISBibTeXText

PMID: 27178019

DOI: 10.1016/j.drudis.2016.05.005


Related references

High throughput screening system to detect antioxidants to combat microglial oxidants from neurodegenerative diseases. Journal of Neurochemistry 74(Suppl ): S68, 2000

Classification of 3D Multicellular Organization in Phase Microscopy for High Throughput Screening of Therapeutic Targets. Proceedings. IEEE Workshop on Applications of Computer Vision 2015: 436-441, 2015

Identification and validation of vesicant therapeutic targets using a high-throughput siRNA screening approach. Archives of Toxicology 90(2): 375-383, 2017

A high-throughput siRNA screening platform to identify MYC-synthetic lethal genes as candidate therapeutic targets. Methods in Molecular Biology 1012: 187-200, 2014

A cellular high-throughput screening approach for therapeutic trans-cleaving ribozymes and RNAi against arbitrary mRNA disease targets. Experimental Eye Research 151: 236-255, 2017

Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference. Plos One 8(4): E60334, 2013

Chemical screening platforms for autophagy drug discovery to identify therapeutic candidates for Huntington's disease and other neurodegenerative disorders. Drug Discovery Today. Technologies 10(1): E137-E144, 2014

MicroRNAs: novel therapeutic targets in neurodegenerative diseases. Drug Discovery Today 14(23-24): 1123-1129, 2010

Transglutaminases as possible therapeutic targets in neurodegenerative diseases. Recent Patents on Cns Drug Discovery 5(3): 195-202, 2011

Transglutaminases as Possible Therapeutic Targets in Neurodegenerative Diseases. Recent Patents on Cns Drug Discovery 5(3): 195-202, 2010

High-Content and High-Throughput In Vivo Drug Screening Platforms Using Microfluidics. Assay and Drug Development Technologies 17(1): 8-13, 2019

Platforms for high-throughput screening of Wnt/Frizzled antagonists. Drug Discovery Today 17(23-24): 1316-1322, 2013

Profiling withanolide A for therapeutic targets in neurodegenerative diseases. Bioorganic and Medicinal Chemistry 2019, 2019

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases. Trends in Pharmacological Sciences 33(6): 295-303, 2012

Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms. Analytical Biochemistry 328(2): 131-138, 2004