+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Histological lymphovascular invasion is associated with nodal involvement, recurrence, and survival in patients with cutaneous malignant melanoma

Histological lymphovascular invasion is associated with nodal involvement, recurrence, and survival in patients with cutaneous malignant melanoma

International Journal of Dermatology 56(2): 166-170

Invasion of the lymphatic or vascular vessels by the primary tumor is considered a sign of aggressive disease that leads to metastases to the regional lymph nodes and to distant sites. Although lymphovascular invasion (LVI) is one of the major characteristics of a primary melanoma tumor, its prognostic significance remains controversial. The objective of this study was to determine the clinical significance of LVI in melanoma patients. Outcomes in 705 patients with cutaneous melanoma were investigated retrospectively. The median age of the patients was 52 years (range: 16-104 years). Of the 705 patients, 624 (88.5%) did not have LVI and 81 (11.5%) patients did. Melanoma patients with LVI more frequently had nodular pathology (P = 0.001), invasion to an advanced Clark level (P = 0.000), greater Breslow thickness (P = 0.000), a high mitotic rate (P = 0.018), ulceration (P = 0.000), neurotropism (P = 0.000), lymph node involvement (P = 0.000), multiple lymph node involvement (P = 0.008), recurrent disease (P = 0.003), and metastatic disease (P = 0.008) than those without LVI. However, LVI was not significantly associated with age, gender, anatomic localization, tumor-infiltrating lymphocytes, vertical growth phase, a pre-existing melanocytic nevus, or type of distant metastasis. Lymphovascular invasion was significantly associated with both recurrence-free (P = 0.000) and overall (P = 0.000) survival. On multivariate analyses, although LVI was not independently associated with RFS (P = 0.134), it retained its significance for overall survival (P = 0.000). Lymphovascular invasion has significant prognostic impact on nodal involvement, recurrence, and overall survival in cutaneous melanoma.

(PDF emailed within 0-6 h: $19.90)

Accession: 058000633

Download citation: RISBibTeXText

PMID: 27778319

DOI: 10.1111/ijd.13405

Related references

Tumor Infiltrating Lymphocytes (TILs) May be Only an Independent Predictor of Nodal Involvement but not for Recurrence and Survival in Cutaneous Melanoma Patients. Cancer Investigation 35(8): 501-505, 2017

Associations between lymphovascular space invasion, nodal recurrence, and survival in patients with surgical stage I endometrioid endometrial adenocarcinoma. World Journal of Surgical Oncology 17(1): 80, 2019

Anemia in Cutaneous Malignant Melanoma: Low Blood Hemoglobin Level is Associated with Nodal Involvement, Metastatic Disease, and Worse Survival. Nutrition and Cancer 70(2): 236-240, 2017

A retrospective histological study of 669 cases of primary cutaneous malignant melanoma in clinical stage i 6. the relation of dermal solar elastosis to sex age and survival of the patient and to localization histological type and level of invasion of the tumor. Acta Pathologica et Microbiologica Scandinavica Section A Pathology 87(5): 361-366, 1979

A RETROSPECTIVE HISTOLOGICAL STUDY OF 669 CASES OF PRIMARY CUTANEOUS MALIGNANT MELANOMA IN CLINICAL STAGE I : 6. The Relation of Dermal Solar Elastosis to Sex, Age and Survival of the Patient and to Localization, Histological Type and Level of Invasion of the Tumour. Apmis 87a(1-6): 361-366, 1979

Mitotic rate and subcutaneous involvement are prognostic factors for survival after recurrence in patients with only locoregional skin metastasis as the first site of recurrence from cutaneous melanoma. Journal of the European Academy of Dermatology and Venereology 27(4): 436-441, 2013

Lymphovascular Invasion is Independently Associated With Overall Survival, Cause-Specific Survival, and Local and Distant Recurrence in Patients With Negative Lymph Nodes at Radical Cystectomy. Journal of Urology 175(5): 1653-1654, 2006

Lymphovascular invasion is independently associated with overall survival, cause-specific survival, and local and distant recurrence in patients with negative lymph nodes at radical cystectomy. Journal of Clinical Oncology 23(27): 6533-6539, 2005

Nuclear survivin is associated with disease recurrence and poor survival in patients with cutaneous malignant melanoma. Histopathology 50(7): 835-842, 2007

Microvessel density, lymphovascular density, and lymphovascular invasion in primary cutaneous melanoma-correlation with histopathologic prognosticators and BRAF status. Human Pathology 46(2): 304-312, 2015

Patient age and cutaneous malignant melanoma: Elderly patients are likely to have more aggressive histological features and poorer survival. Molecular and Clinical Oncology 7(6): 1083-1088, 2017

Stage-specific survival and recurrence in patients with cutaneous malignant melanoma in Europe - a systematic review of the literature. Clinical Epidemiology 8: 109-122, 2016

An incidental finding of a nodal recurrence of cutaneous malignant melanoma after a 45-year disease-free period. Bmj Case Reports 2014, 2015

Conditional recurrence-free survival in patients with primary stage I-II cutaneous malignant melanoma - a population-based study. Melanoma Research 28(6): 637-640, 2018

The Impact of Lymphovascular Space Invasion on Recurrence and Survival in Iranian Patients With Early Stage Endometrial Cancer. World Journal of Oncology 7(4): 70-74, 2016