+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Human Fitting Studies of Cleveland Clinic Continuous-Flow Total Artificial Heart



Human Fitting Studies of Cleveland Clinic Continuous-Flow Total Artificial Heart



Asaio Journal 61(4): 424-428



Implantation of mechanical circulatory support devices is challenging, especially in patients with a small chest cavity. We evaluated how well the Cleveland Clinic continuous-flow total artificial heart (CFTAH) fit the anatomy of patients about to receive a heart transplant. A mock pump model of the CFTAH was rapid-prototyped using biocompatible materials. The model was brought to the operative table, and the direction, length, and angulation of the inflow/outflow ports and outflow conduits were evaluated after the recipient's ventricles had been resected. Thoracic cavity measurements were based on preoperative computed tomographic data. The CFTAH fit well in all five patients (height, 170 ± 9 cm; weight, 75 ± 24 kg). Body surface area was 1.9 ± 0.3 m (range, 1.6-2.1 m). The required inflow and outflow port orientation of both the left and right housings appeared consistent with the current version of the CFTAH implanted in calves. The left outflow conduit remained straight, but the right outflow direction necessitated a 73 ± 22 degree angulation to prevent potential kinking when crossing over the connected left outflow. These data support the fact that our design achieves the proper anatomical relationship of the CFTAH to a patient's native vessels.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058015974

Download citation: RISBibTeXText

PMID: 25806613

DOI: 10.1097/mat.0000000000000219


Related references

In Vivo Evaluation of the Cleveland Clinic Continuous-Flow Total Artificial Heart in Calves. Journal of Heart and Lung Transplantation 33(4): S165-S166, 2014

Mechanism of Self-Regulation and In Vivo Performance of the Cleveland Clinic Continuous-Flow Total Artificial Heart. Artificial Organs 41(5): 411-417, 2017

Sensorless Suction Recognition in the Self-Regulating Cleveland Clinic Continuous-Flow Total Artificial Heart. Asaio Journal 61(6): 726-728, 2015

In vivo acute performance of the Cleveland Clinic self-regulating, continuous-flow total artificial heart. Journal of Heart and Lung Transplantation 29(1): 21-26, 2010

Anatomical study of the Cleveland Clinic continuous-flow total artificial heart in adult and pediatric configurations. Journal of Artificial Organs 21(3): 383-386, 2018

Simulated Performance of the Cleveland Clinic Continuous-Flow Total Artificial Heart Using the Virtual Mock Loop. Asaio Journal 65(6): 565-572, 2019

The Cleveland Clinic-Nimbus total artificial heart. In vivo hemodynamic performance in calves and preclinical studies. Journal of Thoracic and Cardiovascular Surgery 108(3): 420-428, 1994

Progress in Cleveland Clinic-Nimbus total artificial heart development. Asaio Journal 40(3): M494, 1994

Continuing development of the Cleveland Clinic-Nimbus total artificial heart. Asaio Journal 39(3): M168, 1993

The Cleveland Clinic-Nimbus total artificial heart. Design and in vitro function. Journal of Thoracic and Cardiovascular Surgery 108(3): 412-419, 1994

Development of a flow transformed pulsatile total artificial heart for total implantation-minimization of arterial and venous blood mixture in continuous flow pump. Japanese Journal of Artificial Organs 23(1): 60-64, 1994

Anatomic Fitting Studies of a Total Artificial Heart in Heart Transplant Recipients. Asaio Journal 42(5): M337-341, 1996

Cleveland Clinic PediPump lamb cadaver fitting studies. Artificial Organs 31(5): 405-408, 2007

Anatomic fitting studies of a total artificial heart in heart transplant recipients. Critical dimensions and prediction of fit. Asaio Journal 42(5): M337, 1996

The Cleveland Clinic PediPump: anatomic modeling and virtual fitting studies in a lamb model. Asaio Journal 53(6): 716-719, 2007