+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Hyaluronic acid versus saline intra-articular injections for amelioration of chronic knee osteoarthritis: A canine model



Hyaluronic acid versus saline intra-articular injections for amelioration of chronic knee osteoarthritis: A canine model



Journal of Orthopaedic Research 34(10): 1772-1779



The objective of this study was to assess the safety and efficacy of intra-articular injections of hyaluronic acid (HA) versus saline for symptomatic treatment of osteoarthritis (OA). Twenty-five adult purpose-bred dogs underwent meniscal release of one knee. Clinical, arthroscopic, and radiographic signs of OA were confirmed in all dogs prior to treatment. Dogs were randomized into five groups: HA-1 (n = 5), HA-3 (n = 5), HA-5 (n = 5), Saline-1 (n = 5), and Saline-3 (n = 5). Each dog received intra-articular injections of the respective substance into the affected knee at the pre-determined time points. Dogs were assessed for heat, swelling, and erythema after each injection and for lameness, pain, effusion, range of motion, kinetics, radiographic OA scoring, and arthroscopic scoring prior to treatment and for 6 months after injection. Dogs were then humanely euthanatized and the knees assessed grossly and histologically. Only mild heat, swelling, and/or erythema were noted in some dogs following injection and resolved within 1 week. Dogs treated with HA-1, HA-3, and HA-5 were significantly (p < 0.05) better than dogs treated with Saline-1 and Saline-3 at the 4, 8, and 12 week time points based on at least one outcome measure. OA severity was not significantly different among groups at any time point, but increased in severity over time in all groups. Gross and histologic OA scores were not significantly different among groups. These data suggest the three HA injection protocols were safe, superior to saline for short-term amelioration of symptoms associated with chronic OA, and can be translated to human OA treatment. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1772-1779, 2016.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058020269

Download citation: RISBibTeXText

PMID: 26867692

DOI: 10.1002/jor.23191


Related references

Effects of intra-articular injections of hyaluronic acid on joint pathology and articular cartilage biochemistry in a canine model of osteoarthritis. Arthritis & Rheumatism 40(9 Suppl. ): S88, 1997

Effect of Extracorporeal Shockwave Therapy Versus Intra-articular Injections of Hyaluronic Acid for the Treatment of Knee Osteoarthritis. Annals of Rehabilitation Medicine 41(5): 828-835, 2017

Do intra-articular hyaluronic acid injections delay total knee replacement in patients with osteoarthritis - A Cox model analysis. Plos one 12(11): E0187227, 2017

US-Approved Intra-Articular Hyaluronic Acid Injections are Safe and Effective in Patients with Knee Osteoarthritis: Systematic Review and Meta-Analysis of Randomized, Saline-Controlled Trials. Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders 6: 57-63, 2013

Comparison of hyaluronic acid and PRP intra-articular injection with combined intra-articular and intraosseous PRP injections to treat patients with knee osteoarthritis. Clinical Rheumatology 37(5): 1341-1350, 2018

Intra-articular hyaluronic acid injections for knee osteoarthritis. American Family Physician 62(3): 565-70 572, 2000

Intra-articular injections of hyaluronic acid in the treatment of knee osteoarthritis. Harefuah 140(6): 512-513, 2001

A double-blind trial of intra-articular hyaluronic acid versus intra-articular triamcinolone hexacetonide in knee osteoarthritis. Arthritis & Rheumatism 35(9 Suppl. ): S132, 1992

Intra-articular hyaluronic acid injections. Are they effective treatment for osteoarthritis of the knee?. Canadian Family Physician Medecin de Famille Canadien 49: 435-437, 2003

Long term effects of intra articular injections of hyaluronic acid osteoarthritis of the knee. Arthritis & Rheumatism 34(9 Suppl.): S86, 1991

Kinetics features changes before and after intra-articular hyaluronic acid injections in patients with knee osteoarthritis. Clinical Neurology and Neurosurgery 129(Suppl. 1): S21-S26, 2015

Evaluation of hyaluronic acid intra-articular injections in the treatment of primary and secondary osteoarthritis of the knee. Polish Orthopedics and Traumatology 77: 105-109, 2012

Comparison of intra-articular hyaluronic acid injections and mud-pack therapy in the treatment of knee osteoarthritis. Acta Orthopaedica et Traumatologica Turcica 44(1): 42-47, 2010

Comparison of two different molecular weight intra-articular injections of hyaluronic acid for the treatment of knee osteoarthritis. Hippokratia 20(1): 26-31, 2016

Efficacy of Intra-articular Polynucleotides Associated With Hyaluronic Acid Versus Hyaluronic Acid Alone in the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Clinical Trial. Clinical Journal of Sport Medicine 2018:, 2018