+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Identification of miRNAs as non-invasive biomarkers for early diagnosis of lung cancers



Identification of miRNAs as non-invasive biomarkers for early diagnosis of lung cancers



Tumour Biology 2016



Current clinical diagnostic methods lack the specificity in detecting lung cancer patients. The issue is particularly critical for stage I and II patients. Considerable evidence showed microRNA plays a very important role in lung carcinogenesis. Here, we identified a panel of 41 miRNAs significantly elevated in patients with lung cancer, of which eight miRNAs were further validated in an independent sample cohort. Classification analysis using the panel of eight miRNAs generated a discriminatory power of 93.3 % sensitivity and 93.8 % specificity in separating non-small-cell lung cancer (NSCLC) patients from normal controls, indicating the miRNAs have a potential clinical utility in discriminating NSCLC. Interestingly, miR-1244 was found significantly elevated in the serum samples of lung cancer patients, and the test characteristics of the single miRNA were area under the curve (AUC) of 0.832 in NSCLC vs healthy controls, and 0.861 in NSCLC vs patients with unidentified pulmonary nodules. This is the first study showing serum miR-1244 could be a biomarker to screen lung cancer patients from the high-risk population.

(PDF emailed within 0-6 h: $19.90)

Accession: 058039977

Download citation: RISBibTeXText

PMID: 27812928

DOI: 10.1007/s13277-016-5442-y


Related references

miRNAs as non-invasive biomarkers for lung cancer diagnosis. Molecules 19(6): 8220-8237, 2015

Identification of serum miRNAs by nano-quantum dots microarray as diagnostic biomarkers for early detection of non-small cell lung cancer. Tumour Biology 37(6): 7777-7784, 2017

Non-invasive identification of protein biomarkers for early pregnancy diagnosis in the cheetah (Acinonyx jubatus). Plos One 12(12): E0188575, 2018

Identification of non-invasive miRNAs biomarkers for prostate cancer by deep sequencing analysis of urinary exosomes. Molecular Cancer 16(1): 156, 2018

Circulating cell-free DNAs and miRNAs as promising non-invasive biomarkers for early detection of gastric cancer. Neoplasma 63(1): 1-9, 2015

Early diagnosis of asthma in young children by using non-invasive biomarkers of airway inflammation and early lung function measurements: study protocol of a case-control study. Bmc Public Health 9: 210, 2009

Circulating miRNAs 21 and 221 as biomarkers for early diagnosis of prostate cancer. Tumour Biology 35(12): 12613-7, 2015

miRNAs as biomarkers and for the early detection of non-small cell lung cancer (NSCLC). Journal of Thoracic Disease 10(5): 3119-3131, 2018

Circulating miRNAs as biomarkers for early diagnosis of coronary artery disease. Expert Opinion on Therapeutic Patents 28(8): 591-601, 2018

Analysis of circulating miRNAs 21 and 375 as potential biomarkers for early diagnosis of prostate cancer. Neoplasma 63(4): 623-628, 2016

Identification of Serological Biomarkers for Early Diagnosis of Lung Cancer Using a Protein Array-Based Approach. Molecular and Cellular Proteomics 16(12): 2069-2078, 2017

The clinical use of circulating microRNAs as non-invasive diagnostic biomarkers for lung cancers. Oncotarget 8(52): 90197-90214, 2017

Altered expression levels of miRNAs in serum as sensitive biomarkers for early diagnosis of traumatic injury. Journal of Cellular Biochemistry 112(9): 2435-2442, 2011

MiRNAs which target CD3 subunits could be potential biomarkers for cancers. Plos One 8(11): E78790, 2014

Meta-Analysis of miRNAs and Their Involvement as Biomarkers in Oral Cancers. Biomed Research International 2018: 8439820, 2018