+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ifenprodil infusion in agranular insular cortex alters social behavior and vocalizations in rats exposed to moderate levels of ethanol during prenatal development



Ifenprodil infusion in agranular insular cortex alters social behavior and vocalizations in rats exposed to moderate levels of ethanol during prenatal development



Behavioural Brain Research 320: 1-11



Moderate exposure to alcohol during development leads to subtle neurobiological and behavioral effects classified under the umbrella term fetal alcohol spectrum disorders (FASDs). Alterations in social behaviors are a frequently observed consequence of maternal drinking, as children with FASDs display inappropriate aggressive behaviors and altered responses to social cues. Rodent models of FASDs mimic the behavioral alterations seen in humans, with rats exposed to ethanol during development displaying increased aggressive behaviors, decreased social investigation, and altered play behavior. Work from our laboratory has observed increased wrestling behavior in adult male rats following prenatal alcohol exposure (PAE), and increased expression of GluN2B-containing NMDA receptors in the agranular insular cortex (AIC). This study was undertaken to determine if ifenprodil, a GluN2B preferring negative allosteric modulator, has a significant effect on social behaviors in PAE rats. Using a voluntary ethanol exposure paradigm, rat dams were allowed to drink a saccharin-sweetened solution of either 0% or 5% ethanol throughout gestation. Offspring at 6-8 months of age were implanted with cannulae into AIC. Animals were isolated for 24h before ifenprodil or vehicle was infused into AIC, and after 15min they were recorded in a social interaction chamber. Ifenprodil treatment altered aspects of wrestling, social investigatory behaviors, and ultrasonic vocalizations in rats exposed to ethanol during development that were not observed in control animals. These data indicate that GluN2B-containing NMDA receptors in AIC play a role in social behaviors and may underlie alterations in behavior and vocalizations observed in PAE animals.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058044579

Download citation: RISBibTeXText

PMID: 27888019

DOI: 10.1016/j.bbr.2016.11.036


Related references

Moderate prenatal alcohol exposure enhances GluN2B containing NMDA receptor binding and ifenprodil sensitivity in rat agranular insular cortex. Plos one 10(3): E0118721, 2015

Prenatal exposure to moderate levels of ethanol alters social behavior in adult rats: relationship to structural plasticity and immediate early gene expression in frontal cortex. Behavioural Brain Research 207(2): 290-304, 2010

Patterns of social-experience-related c-fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development. Behavioural Brain Research 214(1): 66-74, 2010

Effects of sex and housing on social, spatial, and motor behavior in adult rats exposed to moderate levels of alcohol during prenatal development. Behavioural Brain Research 313: 233-243, 2016

Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats. Psychopharmacology 234(16): 2431-2441, 2017

Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. International Journal of Developmental Neuroscience 31(8): 740-750, 2013

Docosahexaenoic acid partially ameliorates deficits in social behavior and ultrasonic vocalizations caused by prenatal ethanol exposure. Behavioural Brain Research 286: 201-211, 2015

Involvement of the rostral agranular insular cortex in nicotine self-administration in rats. Behavioural Brain Research 290: 77-83, 2015

Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior. Behavioural Brain Research 269: 44-54, 2014

Prenatal Ethanol Exposure and Whisker Clipping Disrupt Ultrasonic Vocalizations and Play Behavior in Adolescent Rats. Brain Sciences 6(4):, 2016

Prenatal methylazoxymethanol acetate alters behavior and brain NGF levels in young rats: A possible correlation with the development of schizophrenia-like deficits. Neuropharmacology 38(6): 857-869, 1999

Modulation of ventral-striatal dopamine levels by agranular insular cortex activity is dependent upon behavioral context. Society for Neuroscience Abstracts 26(1-2): Abstract No -845 17, 2000

The role of the agranular insular cortex in working memory for food reward value and allocentric space in rats. Behavioural Brain Research 98(1): 103-112, 1999

A subgroup of ouput neurons from the rats rostral agranular insular cortex expresses GABAB receptors. Society for Neuroscience Abstracts 26(1-2): Abstract No -157 3, 2000

Moderate prenatal alcohol exposure alters behavior and neuroglial parameters in adolescent rats. Behavioural Brain Research 269: 175-184, 2014