+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Impaired Tilt Suppression of Post-Rotatory Nystagmus and Cross-Coupled Head-Shaking Nystagmus in Cerebellar Lesions: Image Mapping Study



Impaired Tilt Suppression of Post-Rotatory Nystagmus and Cross-Coupled Head-Shaking Nystagmus in Cerebellar Lesions: Image Mapping Study



Cerebellum 16(1): 95-102



We sought to determine the cerebellar structures responsible for tilt suppression of post-rotatory nystagmus. We investigated ocular motor findings and MRI lesions in 73 patients with isolated cerebellar lesions who underwent recording of the vestibulo-ocular reflex (VOR) using rotatory chair tests. Tilt suppression of post-rotatory nystagmus was diminished in 27 patients (27/73, 37.0 %). The gains of the VOR and the TCs of per- and post-rotatory nystagmus did not differ between the patients with diminished and with normal tilt suppression. The patients with impaired tilt suppression showed perverted ("cross-coupled") head-shaking nystagmus (pHSN) and central positional nystagmus (CPN) more frequently than those with normal responses. Tilt suppression was impaired in five (71.4 %) of the seven patients with isolated nodulus and uvular infarction. Probabilistic lesion-mapping analysis showed that the nodulus and uvula are responsible for tilt suppression. Impaired tilt suppression may be ascribed to disruption of cerebellar contribution to the vestibular velocity-storage mechanism, which integrates information from the semicircular canals and otolith organs to help derive the brain's estimate of the head orientation relative to the pull of gravity.

(PDF emailed within 0-6 h: $19.90)

Accession: 058065473

Download citation: RISBibTeXText

PMID: 26969184

DOI: 10.1007/s12311-016-0772-2


Related references

Tilt suppression, OKAN, and head-shaking nystagmus at long-term follow-up after unilateral vestibular neurectomy. Journal of Vestibular Research 6(4): 235-241, 1996

Diagnostic confirmation of lesions in cerebellar peduncles by combined use of optokinetic nystagmus and fixation-suppression of caloric nystagmus. Advances in Oto-Rhino-Laryngology 42: 202-204, 1988

Suppression of post rotatory nystagmus depends on amplitude not final position of active head movements. Society for Neuroscience Abstracts 13(2): 1313, 1987

The effect of lateral head tilt on head-shaking nystagmus. Taguchi, K, Igarashi, M, Mori, S International Congress Series; Vestibular and neural front 573-574, 1994

Revaluation of the Head Shaking Test as a Method of Nystagmus Provocation. 1. its Nystagmus-Eliciting Effect. Nihon Jibiinkoka Gakkai Kaiho 67: 1530-1534, 1964

Relations of rotatory after-nystagmus and contralateral horizontal nystagmus in different head positions. Monatsschrift für Ohrenheilkunde und Laryngo-Rhinologie 105(2): 61-66, 1971

Transformation of rotatory post-rotational nystagmus into horizontal nystagmus with a reverse direction. Vestnik Otorinolaringologii 33(1): 12-14, 1971

Post rotatory nystagmus and opto kinetic after nystagmus in the rabbit linear rather than exponential decay. Experimental Brain Research 40(3): 330-338, 1980

Clinical significance of vibration-induced nystagmus and head-shaking nystagmus through follow-up examinations in patients with vestibular neuritis. Otology and Neurotology 29(3): 375-379, 2008

Plane-specific reorientation of post-rotatory nystagmus during static roll tilt in the cat. Society for Neuroscience Abstracts 27(1): 1061, 2001

Isolated perverted head-shaking nystagmus in focal cerebellar infarction. Neurology 64(3): 575-576, 2005

Patterns of spontaneous and head-shaking nystagmus in cerebellar infarction: imaging correlations. Brain 134(Pt 12): 3662-3671, 2012

A visual suppression test using post-rotatory nystagmus. Auris, Nasus, Larynx 19(2): 83-94, 1992

Pharmacology of the vestibulo-ocular reflex. II. Action of cholinesterase antagonists on post-rotatory nystagmus in rabbits; use of an electronic integrator in evaluating the nystagmus response. Archives Internationales de Pharmacodynamie et de Therapie 99(2): 206-214, 1954

Transitory counterrolling and pure rotatory positioning nystagmus caused by cerebellar vermis lesions. Practica Otologica Kyoto 78(12): 2729-2736, 1985