+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Inhibition of Oral Streptococci Growth Induced by the Complementary Action of Berberine Chloride and Antibacterial Compounds



Inhibition of Oral Streptococci Growth Induced by the Complementary Action of Berberine Chloride and Antibacterial Compounds



Molecules 20(8): 13705-13724



Synergistic interactions between natural bioactive compounds from medicinal plants and antibiotics may exhibit therapeutic benefits, acting against oral cariogenic and opportunistic pathogens. The aim of the presented work was to assess the antibacterial activity of berberine chloride (BECl) in light of the effect exerted by common antibiotics on selected reference strains of oral streptococci (OST), and to evaluate the magnitude of interactions. Three representative oral microorganisms were investigated: Streptococcus mutans ATCC 25175 (SM), S. sanguinis ATCC 10556 (SS), S. oralis ATCC 9811 (SO) and microdilution tests, along with disc diffusion assays were applied. Here, we report that growth (viability) of all oral streptococci was reduced by exposure to BECl and was dependent primarily on exposure/ incubation time. A minimum inhibitory concentrations (MIC) of BECl against OST ranged from 512 µg/mL (SS) to 1024 µg/mL (SM, SO). The most noticeable antibacterial effects were observed for S. sanguinis (MIC 512 µg/mL) and the most significant synergistic action was found for the combinations BECl-penicillin, BECl-clindamycin and BECl-erythromycin. The S. oralis reflects the highest MBC value as assessed by the AlamarBlue assay (2058 µg/mL). The synergy between berberine and common antibiotics demonstrates its potential use as a novel antibacterial tool for opportunistic infections and also provides a rational basis for the use of berberine as an oral hygiene measure.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058119175

Download citation: RISBibTeXText

PMID: 26225951

DOI: 10.3390/molecules200813705


Related references

The antagonism of the antibacterial action of mercury compounds. Part I. The antibacterial activity of mercuric chloride. Journal of Pharmacy and Pharmacology 11: 666-670, 1959

The antagonism of the antibacterial action of mercury compounds. Part V. Quantitative aspects of the antagonism of the antibacterial action of mercuric chloride. Journal of Pharmacy and Pharmacology 12: 219-226, 1960

Antibacterial action of honey on oral streptococci. Journal of the Dental Association of South Africa 49(7): 339-341, 1994

The antagonism of the antibacterial action of mercury compounds. Part II. Factors affecting the action of mercuric chloride. Journal of Pharmacy and Pharmacology 11: 729-736, 1959

Toxic action of phenolic compounds and sodium chloride in model systems Phytotoxicity, inhibition of plant growth.1. Izvestiia Akademii nauk Kazakhskoi SSR Seriia biologicheskaia: (3) 10-14, 1982

Influence of zinc chloride mouth rinsings on caries induced plaque streptococci second information in vivo studies of the antibacterial efficiency of zinc chloride on the total streptococcus flora of dental plaque. Zahn- Mund- und Kieferheilkunde 78(5): 393-396, 1990

Antibacterial compounds of Canadian honeys target bacterial cell wall inducing phenotype changes, growth inhibition and cell lysis that resemble action of β-lactam antibiotics. Plos One 9(9): E106967-E106967, 2016

Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels. Frontiers in Physiology 2: 33-33, 2011

Antagonistic action of phenolic compounds on abscisic acid induced inhibition of hypocotyl growth. Journal of Experimental Botany 31(125): 1651-1656, 1980

Influence of zinc chloride mouth rinsings on caries induced plaque streptococci third information. antibacterial efficiency of zinc chloride on the species streptococcus mutans streptococcus sanguis and streptococcus salivarius in the dental plaque. Zahn- Mund- und Kieferheilkunde 78(6): 501-505, 1990

Copper-inhibition of the growth of oral streptococci and actinomyces. Biomaterials 4(3): 225-227, 1983

Inhibition of growth of oral streptococci by xylitol l sorbose and mannitol. Journal of Dental Research 61(SPEC ISSUE): 191, 1982

p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Molecular Carcinogenesis 48(1): 24-37, 2009

Berberine-induced growth inhibition of epithelial ovarian carcinoma cell lines. Journal of Obstetrics and Gynaecology Research 38(3): 535-540, 2012

Antibacterial activity of various antibiotics against oral streptococci isolated in the oral cavity. International Journal of Immunopathology and Pharmacology 25(3): 805-809, 2012