+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Development of glucocorticoid resistance over one year among mothers of children newly diagnosed with cancer



Development of glucocorticoid resistance over one year among mothers of children newly diagnosed with cancer



Brain, Behavior, and Immunity 69: 364-373



Chronic distress associates with peripheral release of cortisol and a parallel upregulation of innate inflammation. Typically, cortisol functions to down-regulate inflammatory processes. However, in the context of chronic stress, it is hypothesized that glucocorticoid receptors within immune cells become less sensitive to the anti-inflammatory effects of cortisol, resulting in increased systemic inflammation. Caring for a child newly diagnosed with cancer is a particularly provocative chronic stressor. Here, we examine evidence for the development of cellular resistance to glucocorticoids among 120 mothers (Aged 18-56 years; 86% Caucasian) across the 12 months following their child's new diagnosis with cancer. Measures of psychological distress, interleukin (IL)-6, and glucocorticoid resistance (GCR) were assessed 1, 6, and 12 months after the diagnosis. A latent factor for distress was derived from the covariation among symptoms of anxiety, depression, and post-traumatic stress. Latent change score models revealed a significant positive association between change in distress and change in GCR from 0 to 6 months, and 6 months-1 year. This finding provides initial evidence for a longitudinal association between change in maternal distress and change in GCR from the onset of a chronic stressor through one year. Although levels of IL-6 increased during the first six months after the child's diagnosis, the magnitude of this change was not related to change in distress or change in GCR. Given the possible health consequences of reduced immune sensitivity to glucocorticoids, future work should further explore this stress response and its clinical significance.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058125624

Download citation: RISBibTeXText

PMID: 29269321

DOI: 10.1016/j.bbi.2017.12.011


Related references

Development of glucocorticoid resistance over one year among mothers of children newly diagnosed with cancer. Brain, Behavior, and Immunity 66: E4-E5, 2017

Impaired development of bone mineral density in newly diagnosed children with cancer A 1-year prospective study. Acta Paediatrica Supplement (433): 160, 1999

Quality of life in children newly diagnosed with cancer and their mothers. Health and Quality of Life Outcomes 3(): 29-29, 2005

Predictors and mediators of psychological adjustment in mothers of children newly diagnosed with cancer. Psycho-Oncology 13(9): 630-641, 2004

Innate immune markers in mothers and fathers of children newly diagnosed with cancer. Neuroimmunomodulation 15(2): 102-107, 2008

Trajectories of adjustment in mothers of children with newly diagnosed cancer: a natural history investigation. Journal of Pediatric Psychology 32(7): 771-782, 2007

A clinic-based interdisciplinary intervention for mothers of children newly diagnosed with cancer: a pilot study. Journal of Pediatric Psychology 37(10): 1104-1115, 2014

Impact of a parent-based interdisciplinary intervention for mothers on adjustment in children newly diagnosed with cancer. Journal of Pediatric Psychology 38(5): 531-540, 2014

Problem-solving skills training for mothers of children with newly diagnosed cancer: a randomized trial. Journal of Developmental and Behavioral Pediatrics 23(2): 77-86, 2002

Alterations in bone turnover and impaired development of bone mineral density in newly diagnosed children with cancer: a 1-year prospective study. Journal of Clinical Endocrinology and Metabolism 84(9): 3174-3181, 1999

Alterations in bone turnover and impaired development of bone mineral density in newly diagnosed children with cancer - A 1-year prospective analysis. Hormone Research (Basel) 51(SUPPL 2): 120, 1999

Specificity of problem-solving skills training in mothers of children newly diagnosed with cancer: results of a multisite randomized clinical trial. Journal of Clinical Oncology 31(10): 1329-1335, 2013

Using problem-solving skills training to reduce negative affectivity in mothers of children with newly diagnosed cancer: report of a multisite randomized trial. Journal of Consulting and Clinical Psychology 73(2): 272-283, 2005

Health-related quality of life in children with newly diagnosed cancer: a one year follow-up study. Health and Quality of Life Outcomes 4(): 63-63, 2006

Report from a multi-institutional randomized clinical trial examining computer-assisted problem-solving skills training for English- and Spanish-speaking mothers of children with newly diagnosed cancer. Journal of Pediatric Psychology 34(5): 551-563, 2009