EurekaMag
+ Translate
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Integration of a Radiosensitivity Molecular Signature into the Assessment of Local Recurrence Risk in Breast Cancer


Integration of a Radiosensitivity Molecular Signature into the Assessment of Local Recurrence Risk in Breast Cancer



International Journal of Radiation Oncology Biology Physics 93(3): 631-638



ISSN/ISBN: 0360-3016

PMID: 26461005

DOI: 10.1016/j.ijrobp.2015.06.021

Recently, we developed radiosensitivity (RSI), a clinically validated molecular signature that estimates tumor radiosensitivity. In the present study, we tested whether integrating RSI with the molecular subtype refines the classification of local recurrence (LR) risk in breast cancer. RSI and molecular subtype were evaluated in 343 patients treated with breast-conserving therapy that included whole-breast radiation therapy with or without a tumor bed boost (dose range 45-72 Gy). The follow-up period for patients without recurrence was 10 years. The clinical endpoint was LR-free survival. Although RSI did not uniformly predict for LR across the entire cohort, combining RSI and the molecular subtype identified a subpopulation with an increased risk of LR: triple negative (TN) and radioresistant (reference TN-radioresistant, hazard ratio [HR] 0.37, 95% confidence interval [CI] 0.15-0.92, P=.02). TN patients who were RSI-sensitive/intermediate had LR rates similar to those of luminal (LUM) patients (HR 0.86, 95% CI 0.47-1.57, P=.63). On multivariate analysis, combined RSI and molecular subtype (P=.004) and age (P=.001) were the most significant predictors of LR. In contrast, integrating RSI into the LUM subtype did not identify additional risk groups. We hypothesized that radiation dose escalation was affecting radioresistance in the LUM subtype and serving as a confounder. An increased radiation dose decreased LR only in the luminal-resistant (LUM-R) subset (HR 0.23, 95% CI 0.05-0.98, P=.03). On multivariate analysis, the radiation dose was an independent variable only in the LUMA/B-RR subset (HR 0.025, 95% CI 0.001-0.946, P=.046), along with age (P=.008), T stage (P=.004), and chemotherapy (P=.008). The combined molecular subtype-RSI identified a novel molecular subpopulation (TN and radioresistant) with an increased risk of LR after breast-conserving therapy. We propose that the combination of RSI and molecular subtype could be useful in guiding radiation therapy-based decisions in breast cancer.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058131543

Download citation: RISBibTeXText

Related references

Integration of a Radiosensitivity Molecular Signature Into the Assessment of Local Recurrence Risk in Breast Cancer. Breast Diseases: A Year Book Quarterly 27(1): 76-77, 2016

Validation of a Radiosensitivity Molecular Signature in Breast Cancer. Breast Diseases: A Year Book Quarterly 24(2): 185-186, 2013

Validation of a radiosensitivity molecular signature in breast cancer. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 18(18): 5134-5143, 2012

A 95-gene signature stratifies recurrence risk of invasive disease in ER-positive, HER2-negative, node-negative breast cancer with intermediate 21-gene signature recurrence scores. Breast Cancer Research and Treatment 189(2): 455-461, 2021

Radiosensitivity molecular signature could predict therapeutic benefit in breast cancer patients. Biomarkers in Medicine 6(5): 637, 2012

Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients. Acta Oncologica 56(1): 59-67, 2017

A case-control study to identify molecular risk factors for local recurrence in young breast cancer patients. RadioTherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology 156: 127-135, 2021

Molecular biological markers HER-2/NEU and its transcriptional regulator AP2 as risk factors for local recurrence in the conservatively treated breast cancer patient. International Journal of Oncology 11(Suppl ): 926, 1997

Search for a gene expression signature of breast cancer local recurrence in young women. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 18(6): 1704-1715, 2012

Histological determinants for different types of local recurrence after breast-conserving therapy of invasive breast cancer. Dutch Study Group on local Recurrence after Breast Conservation (BORST). European Journal of Cancer 35(13): 1828-1837, 1999

Family history of breast cancer and local recurrence after breast-conserving therapy. the Dutch Study Group on Local Recurrence after Breast Conservation (BORST). European Journal of Cancer 35(4): 620-626, 1999

Breast cancer local recurrence: risk factors and prognostic relevance of early time to recurrence. World Journal of Surgery 31(1): 36-45, 2007

Local recurrence after conservative therapy of breast cancer: risk factors, site of recurrence, evolution. Bulletin du Cancer 81(7): 616-624, 1994

High local recurrence risk after breast-conserving therapy in node-negative premenopausal breast cancer patients is greatly reduced by one course of perioperative chemotherapy: A European Organization for Research and Treatment of Cancer Breast Cancer Cooperative Group Study. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 18(5): 1075-1083, 2000

High local recurrence risk after breast-conserving therapy in node-negative premenopausal breast Cancer Patients is greatly reduced by one course of perioperative chemotherapy : A European Organization for Research and Treatment of Cancer Breast Cancer Cooperative Group Study. European Cancer Conference Ecco 18(5): 1075-1083, 2000