+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats

Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats

Alcohol and Alcoholism 52(1): 1-4

Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats consumed alcohol for 3 months and were subjected to repeated alcohol deprivations for 7-14 days, followed by alcohol reaccess. Upon reaccess, animals consumed 2.2 g alcohol/kg in 60 minutes. A single intra-cerebroventricular MSC administration inhibited relapse-like drinking up to 80-85% for 40 days (P < 0.001). An alcohol-use-disorder was prevented.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 058147037

Download citation: RISBibTeXText

PMID: 27651282

DOI: 10.1093/alcalc/agw068

Related references

Disposition of naltrexone after intravenous bolus administration in Wistar rats, low-alcohol-drinking rats and high-alcohol-drinking rats. Neuropsychobiology 58(2): 81-90, 2008

The Orexin-1 Receptor Antagonist SB-334867 Reduces Alcohol Relapse Drinking, but not Alcohol-Seeking, in Alcohol-Preferring (P) Rats. Journal of Addiction Medicine 4(3): 153-159, 2010

The nociceptin/orphanin FQ receptor agonist Ro 64-6198 reduces alcohol self-administration and prevents relapse-like alcohol drinking. Neuropsychopharmacology 32(4): 902-910, 2006

Effects of periadolescent ethanol drinking on oral ethanol self-administration by adult alcohol preferring rats II Spontaneous recovery and relapse. Alcoholism Clinical & Experimental Research 25(5 Supplement A): 63A, 2001

Effects of acute ethanol administration on body temperature in high alcohol drinking and low alcohol drinking rats. Alcoholism Clinical & Experimental Research 23(5 SUPPL ): 99A, 1999

Effects of relapse alcohol drinking on CNS functional activity of alcohol-preferring rats. Society for Neuroscience Abstracts 27(1): 1185, 2001

Memantine reduces alcohol drinking but not relapse in alcohol-dependent rats. Addiction Biology 20(5): 890-901, 2016

Cocaine influences alcohol-seeking behavior and relapse drinking in alcohol-preferring (P) rats. Alcoholism, Clinical and Experimental Research 38(10): 2678-2686, 2015

Changes in local cerebral glucose utilization following alcohol-relapse drinking in alcohol-preferring rats. Alcoholism Clinical & Experimental Research 24(5 Supplement): 53A, 2000

Scheduled access alcohol drinking by alcohol-preferring (P) and high-alcohol-drinking (HAD) rats: modeling adolescent and adult binge-like drinking. Alcohol 48(3): 225-234, 2015

Intracerebral administration of naloxone and drinking in water-deprived rats. Pharmacology, Biochemistry, and Behavior 15(2): 257-262, 1981

Increased vulnerability to nicotine self-administration and relapse in alcohol-naive offspring of rats selectively bred for high alcohol intake. Journal of Neuroscience 26(6): 1872-1879, 2006

Efficacy of D-penicillamine, a sequestering acetaldehyde agent, in the prevention of alcohol relapse-like drinking in rats. Psychopharmacology 228(4): 563-575, 2014

Local cerebral glucose utilization after relapse in ethanol drinking in alcohol-preferring (P) rats. Alcohol 27(2): 115-126, 2002

Activation of PPARγ by pioglitazone potentiates the effects of naltrexone on alcohol drinking and relapse in msP rats. Alcoholism, Clinical and Experimental Research 37(8): 1351-1360, 2014