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Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats



Intracerebral Stem Cell Administration Inhibits Relapse-like Alcohol Drinking in Rats



Alcohol and Alcoholism 52(1): 1-4



Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats consumed alcohol for 3 months and were subjected to repeated alcohol deprivations for 7-14 days, followed by alcohol reaccess. Upon reaccess, animals consumed 2.2 g alcohol/kg in 60 minutes. A single intra-cerebroventricular MSC administration inhibited relapse-like drinking up to 80-85% for 40 days (P < 0.001). An alcohol-use-disorder was prevented.

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Accession: 058147037

Download citation: RISBibTeXText

PMID: 27651282

DOI: 10.1093/alcalc/agw068


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