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Inversion group (IG) fitting: A new T1 mapping method for modified look-locker inversion recovery (MOLLI) that allows arbitrary inversion groupings and rest periods (including no rest period)



Inversion group (IG) fitting: A new T1 mapping method for modified look-locker inversion recovery (MOLLI) that allows arbitrary inversion groupings and rest periods (including no rest period)



Magnetic Resonance in Medicine 75(6): 2332-2340



The Modified Look-Locker Inversion Recovery (MOLLI) technique is used for T1 mapping in the heart. However, a drawback of this technique is that it requires lengthy rest periods in between inversion groupings to allow for complete magnetization recovery. In this work, a new MOLLI fitting algorithm (inversion group [IG] fitting) is presented that allows for arbitrary combinations of inversion groupings and rest periods (including no rest period). Conventional MOLLI algorithms use a three parameter fitting model. In IG fitting, the number of parameters is two plus the number of inversion groupings. This increased number of parameters permits any inversion grouping/rest period combination. Validation was performed through simulation, phantom, and in vivo experiments. IG fitting provided T1 values with less than 1% discrepancy across a range of inversion grouping/rest period combinations. By comparison, conventional three parameter fits exhibited up to 30% discrepancy for some combinations. The one drawback with IG fitting was a loss of precision-approximately 30% worse than the three parameter fits. IG fitting permits arbitrary inversion grouping/rest period combinations (including no rest period). The cost of the algorithm is a loss of precision relative to conventional three parameter fits. Magn Reson Med 75:2332-2340, 2016. © 2015 Wiley Periodicals, Inc.

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Accession: 058155957

Download citation: RISBibTeXText

PMID: 26122489

DOI: 10.1002/mrm.25829


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