+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Investigating the association between prepregnancy body mass index and adverse pregnancy outcomes: a large cohort study of 536 098 Chinese pregnant women in rural China



Investigating the association between prepregnancy body mass index and adverse pregnancy outcomes: a large cohort study of 536 098 Chinese pregnant women in rural China



BMJ Open 6(6): E011227



Unhealthy maternal weight before pregnancy increases the risk of various adverse pregnancy outcomes. We conducted a nutrition survey to provide baseline data on the prepregnant nutritional status of mothers in order to better understand the association between prepregnancy maternal body mass index (BMI) and adverse pregnancy outcomes. A large, prospective, population-based cohort study. Data from the National Free Preconception Health Examination Project (NFPHEP) in China during 2010-2012. 536 098 pregnant women out of 2 120 131 were evaluated. The primary adverse pregnancy outcomes included preterm birth (PTB), low birth weight (LBW), spontaneous miscarriage (SM), ectopic pregnancy (EP) and stillbirth (SB). A χ(2) test was used to compare the prevalence of each BMI category during 2010-2012. Univariable and multiple logistic regression analyses were performed to assess the association between prepregnancy BMI and various adverse pregnancy outcomes. Between 2010 and 2012, the average BMI decreased from 21.31 to 21.16, while underweight prevalence increased from 10.40% to 14.14%. An age-stratified subgroup analysis indicated that the underweight prevalence increased from 13.52% to 17.02% among women aged 21-24 and from 10.72% to 13.71% among women aged 25-34. Overweight prevalence increased from 9.84% to 10.75% (25-34 years) and from 17.10% to 19.20% (35-49 years). Obesity prevalence increased from 2.17% to 2.42% and from 4% to 4.2% among women aged 25-34 and 35-49 respectively. Prepregnancy underweight was associated with PTB, LBW and SM; overweight women had an increased risk of LBW; obese women had a higher risk of LBW, SM, EP and SB. While the average prepregnancy BMI decreased, the prevalence of underweight individuals in a very large population significantly increased. The abnormal prepregnancy BMIs were associated with increased risks of adverse pregnancy outcomes. Most notably, underweight prepregnant women appeared to be at a greater risk of developing adverse pregnancy outcomes in China's rural areas.

(PDF emailed within 0-6 h: $19.90)

Accession: 058156932

Download citation: RISBibTeXText

PMID: 27439613

DOI: 10.1136/bmjopen-2016-011227


Related references

Risk of adverse pregnancy outcomes by prepregnancy body mass index: a population-based study to inform prepregnancy weight loss counseling. Obstetrics and Gynecology 125(1): 133-143, 2015

First trimester vaginal bleeding and adverse pregnancy outcomes among Chinese women: from a large cohort study in China. Journal of Maternal-Fetal and Neonatal Medicine 25(8): 1297-1301, 2013

Prepregnancy body mass index and adverse pregnancy outcomes. Archives of Gynecology and Obstetrics 278(1): 23-26, 2007

Joint and Independent Associations of Gestational Weight Gain and Pre-Pregnancy Body Mass Index with Outcomes of Pregnancy in Chinese Women: A Retrospective Cohort Study. Plos One 10(8): E0136850, 2016

Pregestational body mass index, gestational weight gain, and risks for adverse pregnancy outcomes among Taiwanese women: A retrospective cohort study. Taiwanese Journal of Obstetrics and Gynecology 55(4): 575-581, 2017

Effects of management in gestational diabetes mellitus with normal prepregnancy body mass index on pregnancy outcomes and placental ultrastructures: a prospective cohort study. Endocrine 54(3): 691-699, 2016

The association of prepregnancy body mass index with pregnancy outcomes in triplet gestations. American Journal of Perinatology 27(1): 41-46, 2010

Prepregnancy body mass index, gestational weight gain, and pregnancy outcomes in China. International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics 109(1): 41-44, 2010

Maternal body mass index and adverse pregnancy outcomes: A ghanaian cohort study. Obesity 24(1): 215-222, 2016

The mutual effect of pre-pregnancy body mass index, waist circumference and gestational weight gain on obesity-related adverse pregnancy outcomes: A birth cohort study. Plos One 12(6): E0177418, 2017

High pre-pregnancy body mass index and the risk of poor obstetrics outcomes among Asian women using BMI criteria for Asians by World Health Organization Western Pacific Region (WPRO): a large cohort study. Journal of the Medical Association of Thailand 98 Suppl 2(): S101-S107, 2015

Risk of adverse pregnancy outcomes by pre-pregnancy Body Mass Index among Italian population: a retrospective population-based cohort study on 27,807 deliveries. Archives of Gynecology and Obstetrics 2019, 2019

Association between periodontal disease and adverse pregnancy outcomes in a cohort of pregnant women in Jordan. Clinical and Experimental Obstetrics and Gynecology 40(3): 399-402, 2014

Prepregnancy body mass index and gestational weight gain with the outcome of pregnancy: a 13-year study of 292,568 cases in China. Archives of Gynecology and Obstetrics 286(4): 905-911, 2013

Higher prepregnancy body mass index is a risk factor for developing preeclampsia in Maya-Mestizo women: a cohort study. Ethnicity and Health 23(6): 682-690, 2017