+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients

Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients

Microbial Pathogenesis 91: 18-25

The clinical course of infection with Mycobacterium leprae varies widely and depends on the pattern of the host immune response. Dendritic cells play an important role in the activation of the innate and adaptive immune system and seem to be essential for the development of the disease. To analyze the presence of epidermal dendritic cells (CD1a and CD207), plasmacytoid dendritic cells (CD123) and dermal dendrocytes (factor XIIIa) in lesion fragments of leprosy patients, skin samples from 30 patients were studied. These samples were submitted to immunohistochemistry against CD1a, CD207, FXIIIa, and CD123. The results showed a larger number of Langerhans cells, detected with the CD1a or CD207 marker, dermal dendrocytes and plasmacytoid dendritic cells in patients with the tuberculoid form. A positive correlation was observed between the Langerhans cell markers CD1a and CD207 in both the tuberculoid and lepromatous forms, and between Langerhans cells and dermal dendrocytes in samples with the tuberculoid form. The present results indicate the existence of a larger number of dendritic cells in patients at the resistant pole of the disease (tuberculoid) and suggest that the different dendritic cells studied play a role, favoring an efficient immune response against infection with M. leprae.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 058196181

Download citation: RISBibTeXText

PMID: 26639680

DOI: 10.1016/j.micpath.2015.11.013

Related references

TNF-alpha induces the generation of Langerin/(CD207)+ immature Langerhans-type dendritic cells from both CD14-CD1a and CD14+CD1a- precursors derived from CD34+ cord blood cells. European Journal of Immunology 33(7): 2053-2063, 2003

Dermal dendrocytes FXIIIa+ are essential antigen-presenting cells in indeterminate leprosy. American Journal of Dermatopathology 37(4): 269-273, 2015

Immunohistochemical study of epidermal Langerhans cells and dermal dendritic cells in benign and malignant skin lesions characterized by a dermal lymphoid infiltrate consisting either of B-cells or T-cells. Virchows Archiv. A Pathological Anatomy and Histopathology 411(4): 337-343, 1987

Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions. Journal of Leukocyte Biology 84(1): 143-151, 2008

Epitopes for CD1a, CD1b, and CD1c antigens are differentially mapped on Langerhans cells, dermal dendritic cells, keratinocytes, and basement membrane zone in human skin. Journal of the American Academy of Dermatology 27(3): 419-426, 1992

CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells. Journal of Experimental Medicine 207(1): 189-206, 2010

CD207 + CD1a + cells circulate in pediatric patients with active Langerhans cell histiocytosis. Blood 130(17): 1898-1902, 2017

Epidermal Langerhans cells, dermal dendritic cells, and keratinocytes in viral lesions of skin and mucous membranes: an immunohistochemical study. Archives of Dermatological Research 280(4): 220-227, 1988

CD1a+ and CD1a- monocyte-derived dendritic cells In vitro model for dermal dendritic cells?. Journal of Investigative Dermatology 109(2): 257, 1997

Sun exposure rapidly reduces plasmacytoid dendritic cells and inflammatory dermal dendritic cells in psoriatic skin. British Journal of Dermatology 165(4): 792-801, 2011

Dermal CD207-Negative Migratory Dendritic Cells Are Fully Competent to Prime Protective, Skin Homing Cytotoxic T-Lymphocyte Responses. Journal of Investigative Dermatology 139(2): 422-429, 2019

S-100-Negative, CD1a-positive histiocytosis: a new variant with features of both indeterminate cells and interstitial dermal dendrocytes. Archives of Dermatology 147(8): 995-997, 2011

Langerhans cells and dermal dendritic cells capture protein antigens in the skin: possible targets for vaccination through the skin. Immunobiology 215(9-10): 770-779, 2011

Langerhans cells, dermal dendritic cells and monocyte-derived dendritic cells are distinct subsets of myeloid dendritic cells defined by diverse functional properties. Archives of Dermatological Research 295(8-9): 342, 2004

Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. Journal of Immunology 168(2): 782-792, 2002