+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens



Leukotriene signaling in the extinct human subspecies Homo denisovan and Homo neanderthalensis. Structural and functional comparison with Homo sapiens



Archives of Biochemistry and Biophysics 565: 17-24



Mammalian lipoxygenases (LOXs) have been implicated in cell differentiation and in the biosynthesis of pro- and anti-inflammatory lipid mediators. The initial draft sequence of the Homo neanderthalensis genome (coverage of 1.3-fold) suggested defective leukotriene signaling in this archaic human subspecies since expression of essential proteins appeared to be corrupted. Meanwhile high quality genomic sequence data became available for two extinct human subspecies (H. neanderthalensis, Homo denisovan) and completion of the human 1000 genome project provided a comprehensive database characterizing the genetic variability of the human genome. For this study we extracted the nucleotide sequences of selected eicosanoid relevant genes (ALOX5, ALOX15, ALOX12, ALOX15B, ALOX12B, ALOXE3, COX1, COX2, LTA4H, LTC4S, ALOX5AP, CYSLTR1, CYSLTR2, BLTR1, BLTR2) from the corresponding databases. Comparison of the deduced amino acid sequences in connection with site-directed mutagenesis studies and structural modeling suggested that the major enzymes and receptors of leukotriene signaling as well as the two cyclooxygenase isoforms were fully functional in these two extinct human subspecies.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058213669

Download citation: RISBibTeXText

PMID: 25447821

DOI: 10.1016/j.abb.2014.10.012


Related references

Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms. Journal of Lipid Research 54(5): 1397-1409, 2013

Taxonomic differences in deciduous upper second molar crown outlines of Homo sapiens, Homo neanderthalensis and Homo erectus. Journal of Human Evolution 72: 1-9, 2014

Tooth components of mandibular deciduous molars of Homo sapiens sapiens and Homo sapiens neanderthalensis: a radiographic study. American Journal of Physical Anthropology 87(3): 255-262, 1992

The Neanderthals: Homo neanderthalensis or Homo sapiens neanderthalensis? Is there a contradiction between the paleogenetic and the paleoanthropological data?. Unknown, 2000

The relationship of earliest Homo sapiens sapiens and late Homo sapiens neanderthalensis in Central Europe; new early upper Pleistocene fossil hominid finds from Bruhl, FRG, and their morphological and chronological position. American Journal of Physical Anthropology 63(2): 205-206, 1984

The Homo sapiens neanderthalensis/ Homo sapiens sapiens transition in Moravia; chronological and archaeological background. Anthropos (Brno) 23: 237-242, 1986

The evolution of Homo sapiens denisova and Homo sapiens neanderthalensis miRNA targeting genes in the prenatal and postnatal brain. Bmc Genomics 16(Suppl. 13): S4, 2015

Tooth components of homo sapiens sapiens and homo sapiens neanderthalensis a radiographic study. American Journal of Physical Anthropology 78(2): 329, 1989

New finds of Homo sapiens neanderthalensis and Homo sapiens sapiens at Velica Pecina in Yugoslavia. American Journal of Physical Anthropology 60(2): 241, 1983

Absolute dating by radiocarbon- and amino-acid-dating of latest Homo sapiens neanderthalensis and earliest Homo sapiens sapiens in Europe. Etudes et Recherches Archeologiques de l'Universite de Liege: 81-115 (28), 1988

Paleoanthropological diversity a Homo sapiens neanderthalensis in Touraine Decouverte paleoanthropologique un Homo sapiens neanderthalensis en Touraine. Symbioses. octobre; 16: 32-35, 2006

The Homo sapiens neanderthalensis and Homo sapiens sapiens relationship in Central Europe. Anthropologie 14(1-2): 79-81, 1976

Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens. Biochemical Society Transactions 33(Pt 4): 582-585, 2005

Morphological variation in Homo neanderthalensis and Homo sapiens in the Levant: a biogeographic model. Kimbel, W. H., 1993

Mandibular ramus shape variation and ontogeny in Homo sapiens and Homo neanderthalensis. Journal of Human Evolution 121: 55-71, 2018