+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Magnetic resonance cholangiography compared with endoscopic retrograde cholangiography in the diagnosis of primary sclerosing cholangitis



Magnetic resonance cholangiography compared with endoscopic retrograde cholangiography in the diagnosis of primary sclerosing cholangitis



Journal of Research in Medical Sciences 19(12): 1150-1154



Magnetic resonance cholangiography (MRC) has gained popularity for diagnosing primary sclerosing cholangitis (PSC). We determined the accuracy of MRC compared with endoscopic retrograde cholangiography (ERC) for diagnosing PSC. This retrospective case-control study was conducted on patients referred to an outpatient gastroenterology clinic from 2001 to 2013. Patients with established diagnosis of PSC who had undergone MRC and ERC within a 6-month interval were included. Controls were selected from patients who had undergone imaging for reasons other than PSC evaluation. Disease outcome at the study time and liver biochemistry data at diagnosis and 1-year thereafter were retrieved. Diagnostic accuracy of MRC in comparison with ERC was evaluated. A total of 46 definite PSC patients (age at diagnosis = 36.8 ± 11.6 years, 33 male) were found. Diagnostic imaging for PSC was ERC alone in 12, MRC alone in 23, and ERC plus MRC in 11 patients. Controls were 89 patients mostly with bile stones. The sensitivity, specificity, and positive and negative likelihood ratios of MRC was 90.9%, 95.5%, 20.23, and 0.10, respectively. Early PSC was found more frequently by MRC compared with ERC (30.4% vs. 8.3%, P = 0.146). No significant difference was found between imaging modalities with regards to patients' outcome (P = 0.786) or liver biochemistry at diagnosis or 1-year thereafter (P >0.05). Starting diagnostic imaging for PSC with MRC seems better and may provide diagnosis of PSC at its earlier phase. Further studies with larger sample of patients and longer follow-ups are warranted.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 058255707

Download citation: RISBibTeXText

PMID: 25709656


Related references

Diagnosis of primary sclerosing cholangitis: a blinded comparative study using magnetic resonance cholangiography and endoscopic retrograde cholangiography. Gastrointestinal Endoscopy 64(2): 219-223, 2006

Magnetic resonance cholangiography vs endoscopic retrograde cholangiography for diagnosis of primary sclerosing cholangitis A blinded case controlled study. Gastroenterology 116(4 Part 2): A9, 1999

Co19 Blinded Comparative Study Of Magnetic Resonance Cholangiography (Mrc) Versus Endoscopic Retrograde Cholangiography (Erc) In The Diagnosis Of Sclerosing Cholangitis (Sc) In Children. Digestive and Liver Disease 44: S248-S249, 2012

Three-dimensional magnetic resonance cholangiopancreatography with respiratory triggering in the diagnosis of primary sclerosing cholangitis: comparison with endoscopic retrograde cholangiography. Endoscopy 34(12): 984-990, 2002

Diagnosis of primary sclerosing cholangitis: prospective comparison of MR cholangiography with endoscopic retrograde cholangiography. Rofo 169(6): 622-626, 1999

Diagnostic accuracy of magnetic resonance and endoscopic retrograde cholangiography in primary sclerosing cholangitis. Clinical Gastroenterology and Hepatology 4(4): 514-520, 2006

Sclerosing cholangitis with autoimmune pancreatitis versus primary sclerosing cholangitis: comparison on endoscopic retrograde cholangiography, MR cholangiography, CT, and MRI. Acta Radiologica 54(6): 601-607, 2013

Comparison of 3D-IR-TSE-MR-cholangiography with endoscopic retrograde cholangiography in the evaluation of primary sclerosing cholangitis. Gastroenterology 112(4 Suppl. ): A1400, 1997

The role of magnetic resonance imaging and endoscopic retrograde cholangiography in the evaluation of disease activity and severity in primary sclerosing cholangitis. Liver International 38(12): 2329-2339, 2018

Cholangiography by magnetic resonance for detection of cholelithiasis: comparison with endoscopic retrograde cholangiography, operative cholangiography and percutaneous cholangiography. Revista de Gastroenterologia del Peru 26(2): 115-124, 2006

Differential diagnosis of sclerosing cholangitis with autoimmune pancreatitis and periductal infiltrating cancer in the common bile duct at dynamic CT, endoscopic retrograde cholangiography and MR cholangiography. European Radiology 22(11): 2502-2513, 2012

The role of endoscopic retrograde cholangiography in the diagnosis and management of patients with primary sclerosing cholangitis. Clinical Radiology 30(4): 445-450, 1979

Accuracy of magnetic resonance cholangiography as compared to endoscopic retrograde cholangiography in the evaluation of patients with biliary obstruction. Gastroenterology 106(4 Suppl. ): A344, 1994

Diagnostic workup of primary sclerosing cholangitis: the benefit of adding gadoxetic acid-enhanced T1-weighted magnetic resonance cholangiography to conventional T2-weighted magnetic resonance cholangiography. Clinical Radiology 69(5): 499-508, 2014

Diagnosis of sclerosing cholangitis in children: blinded, comparative study of magnetic resonance versus endoscopic cholangiography. Clinics and Research in Hepatology and Gastroenterology 37(6): 596-601, 2013