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Microwave-assisted solid-phase synthesis of side-chain to side-chain lactam-bridge cyclic peptides

Tala, S.R.; Schnell, S.M.; Haskell-Luevano, C.

Bioorganic and Medicinal Chemistry Letters 25(24): 5708-5711

2015

ISSN/ISBN: 1464-3405
PMID: 26555357
DOI: 10.1016/j.bmcl.2015.10.095
Accession: 058316064
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Side-chain to side-chain lactam-bridged cyclic peptides have been utilized as therapeutic agents and biochemical tools. Previous synthetic methods of these peptides need special reaction conditions, form side products and take longer reaction times. Herein, an efficient microwave-assisted synthesis of side-chain to side-chain lactam-bridge cyclic peptides SHU9119 and MTII is reported. The synthesis time and efforts are significantly reduced in the present method, without side product formation. The analytical and pharmacological data of the synthesized cyclic peptides are in accordance with the commercially obtained compounds. This new method could be used to synthesize other side-chain to side-chain lactam-bridge peptides and amenable to automation and extensive SAR compound derivatization.

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