+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Mid-pregnancy fetal growth, uteroplacental Doppler indices and maternal demographic characteristics: role in prediction of stillbirth



Mid-pregnancy fetal growth, uteroplacental Doppler indices and maternal demographic characteristics: role in prediction of stillbirth



Acta Obstetricia et Gynecologica Scandinavica 95(11): 1313-1318



To evaluate the relative value of mid trimester fetal growth, uterine artery Doppler indices and maternal demographics in prediction of stillbirth. Retrospective cohort study; 23 894 singleton pregnancies routinely scanned between 19 and 24 weeks' gestation. Maternal characteristics included age, body mass index, ethnicity and medical history. Fetal biometry indices, birthweight and uterine artery pulsatility index values were converted to percentiles and multivariable logistic regression analysis was performed. The predictive accuracy was assessed using receiver operating characteristic curves analysis. The main outcome was prediction of preterm and term stillbirths. Non-Caucasian ethnicity, femur length centile and uterine artery pulsatility index were significantly associated with the risk of stillbirth (all p < 0.01). The detection rate of screening by maternal factors alone was 19% for all stillbirths, and 12 and 14% for term and preterm stillbirth at a 10% false positive rate, respectively. Using femur length centile alone, the detection rates were 27 and 23%, respectively. Uterine artery pulsatility index alone was able to predict 24 and 31% of term and preterm stillbirths. Screening by combining maternal factors, femur length centile and uterine artery Doppler detected 27 and 35% of term and preterm stillbirths at a 10% false positive rate. Second trimester ultrasound assessment offers an opportunity to identify pregnancies at the highest risk of stillbirth occurring as a consequence of placental dysfunction. This information may be useful to improve pregnancy outcome by identifying women who may benefit from increased ultrasound surveillance and/or timely intervention.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058316327

Download citation: RISBibTeXText

PMID: 27588413

DOI: 10.1111/aogs.13012


Related references

Mid-pregnancy fetal biometry, uterine artery Doppler indices and maternal demographic characteristics: role in prediction of small-for-gestational-age birth. Acta Obstetricia et Gynecologica Scandinavica 95(2): 238-244, 2016

Prediction of stillbirth from maternal demographic and pregnancy characteristics. Ultrasound in Obstetrics & Gynecology 48(5): 607-612, 2016

Prediction of stillbirth from maternal factors, fetal biometry and uterine artery Doppler at 19-24 weeks. Ultrasound in Obstetrics & Gynecology 48(5): 624-630, 2016

Doppler ultrasound of the uteroplacental circulation in the prediction of pregnancy outcome in women with raised maternal serum alpha-fetoprotein. British Journal Of Obstetrics & Gynaecology. 101(6): 477-480, 1994

Three-dimensional power Doppler indices at 18-22 weeks' gestation for prediction of fetal growth restriction or pregnancy-induced hypertension. Archives of Gynecology and Obstetrics 292(1): 75-79, 2015

Role of uteroplacental and fetal Doppler in identifying fetal growth restriction at term. Best Practice & Research. Clinical Obstetrics & Gynaecology (): -, 2016

Transvaginal Doppler ultrasound of the uteroplacental circulation in the early prediction of pre-eclampsia and fetal growth restriction. American Journal of Obstetrics & Gynecology 180(1 PART 2): S19, 1999

Continuous-wave Doppler investigation of uteroplacental vessels in high-risk pregnancies as predictor of fetal growth retardation and pregnancy-induced hypertension. Gynecologic and Obstetric Investigation 38(2): 90-95, 1994

Development of quantitative Doppler indices for uteroplacental and fetal blood flow during the third trimester. Ultrasound In Medicine & Biology. 22(7): 823-835, 1996

Doppler flow velocity waveforms in uteroplacental and fetal circulation in normal pregnancy and pregnancy-induced hypertension. Nihon Sanka Fujinka Gakkai Zasshi 45(7): 643-649, 1993

Effects of short-term maternal fasting in the third trimester of pregnancy on fetal biophysical profile and Doppler indices scores. Archives of Gynecology and Obstetrics 283(3): 461-467, 2011

Sleep position, fetal growth restriction, and late-pregnancy stillbirth: the Sydney stillbirth study. Obstetrics and Gynecology 125(2): 347-355, 2015

Effects of maternal hyperoxia with and without normocapnia in uteroplacental and fetal Doppler studies. Ultrasound in Obstetrics & Gynecology 26(5): 495-499, 2005