+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Molecular Characterization and Meta-Analysis of Gut Microbial Communities Illustrate Enrichment of Prevotella and Megasphaera in Indian Subjects



Molecular Characterization and Meta-Analysis of Gut Microbial Communities Illustrate Enrichment of Prevotella and Megasphaera in Indian Subjects



Frontiers in Microbiology 7: 660



The gut microbiome has varied impact on the wellbeing of humans. It is influenced by different factors such as age, dietary habits, socio-economic status, geographic location, and genetic makeup of individuals. For devising microbiome-based therapies, it is crucial to identify population specific features of the gut microbiome. Indian population is one of the most ethnically, culturally, and geographically diverse, but the gut microbiome features remain largely unknown. The present study describes gut microbial communities of healthy Indian subjects and compares it with the microbiota from other populations. Based on large differences in alpha diversity indices, abundance of 11 bacterial phyla and individual specific OTUs, we report inter-individual variations in gut microbial communities of these subjects. While the gut microbiome of Indians is different from that of Americans, it shared high similarity to individuals from the Indian subcontinent i.e., Bangladeshi. Distinctive feature of Indian gut microbiota is the predominance of genus Prevotella and Megasphaera. Further, when compared with other non-human primates, it appears that Indians share more OTUs with omnivorous mammals. Our metagenomic imputation indicates higher potential for glycan biosynthesis and xenobiotic metabolism in these subjects. Our study indicates urgent need of identification of population specific microbiome biomarkers of Indian subpopulations to have more holistic view of the Indian gut microbiome and its health implications.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058335298

Download citation: RISBibTeXText

PMID: 27242691

DOI: 10.3389/fmicb.2016.00660


Related references

Enrichment and molecular characterization of chloropicrin- and metam-sodium-degrading microbial communities. Applied Microbiology and Biotechnology 66(3): 325-332, 2004

Biodiversity within hot spring microbial mat communities: Molecular monitoring of enrichment cultures. Antonie van Leeuwenhoek 71(1-2): 143-150, 1997

Analysis of microbial communities in the oil reservoir subjected to CO2-flooding by using functional genes as molecular biomarkers for microbial CO2 sequestration. Frontiers in Microbiology 6: 236, 2015

Molecular characterization of microbial communities in a Niigata oil well. 2006

Molecular characterization of microbial communities in a contaminated aquifer. Abstracts of the General Meeting of the American Society for Microbiology 99: 472, 1999

Localized electron transfer rates and microelectrode-based enrichment of microbial communities within a phototrophic microbial mat. Frontiers in Microbiology 5: 11, 2014

Responses of soil microbial communities to water stress: results from a meta-analysis. Ecology 93(4): 930-938, 2012

Molecular characterization of microbial communities in a TCE-contaminated bedrock aquifer. Abstracts of the General Meeting of the American Society for Microbiology 101: 495, 2001

Molecular characterization of microbial communities associated with rock varnish from Socorro, NM. 2005

Characterization of microbial communities in anaerobic bioreactors using molecular probes. Antonie van Leeuwenhoek 68(4): 297-308, 1995

Molecular characterization of microbial communities associated with natural attenuation of chloroethylenes. Bioremediation 4, Vol, 1997

Proteogenomic approaches for the molecular characterization of natural microbial communities. Omics 9(4): 301-333, 2006

Enrichment and molecular analysis of microbial consortia involved in dechlorination of chloroethenes. Agricultural And Biosystems Engineering For A Sustainable World: National Conference On Agricultural Engineering, Hersonissos, Crete, Greece, 23-25 E, . . Op-310, 2008

Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder. Journal of Affective Disorders 207: 300-304, 2016