+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Molecular genetics of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia



Molecular genetics of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia



Journal of Hematology and Oncology 7: 93



According to the 2008 World Health Organization classification, chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia are rare diseases. The remarkable progress in our understanding of the molecular genetics of myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms has made it clear that there are some specific genetic abnormalities in these 3 rare diseases. At the same time, there is considerable overlap among these disorders at the molecular level. The various combinations of genetic abnormalities indicate a multi-step pathogenesis, which likely contributes to the marked clinical heterogeneity of these disorders. This review focuses on the current knowledge and challenges related to the molecular pathogenesis of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia and relationships between molecular findings, clinical features and prognosis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058340703

Download citation: RISBibTeXText

PMID: 25498990

DOI: 10.1186/s13045-014-0093-1


Related references

Specific molecular mutation patterns delineate chronic neutrophilic leukemia, atypical chronic myeloid leukemia, and chronic myelomonocytic leukemia. Haematologica 99(12): E244-E246, 2015

Molecular characterization of atypical chronic myeloid leukemia and chronic neutrophilic leukemia. Medicina Clinica 144(11): 487-490, 2016

The role of peripheral blood, bone marrow aspirate and especially bone marrow trephine biopsy in distinguishing atypical chronic myeloid leukemia from chronic granulocytic leukemia and chronic myelomonocytic leukemia. European Journal of Haematology 83(4): 292-301, 2009

Transformation from atypical chronic myeloid leukemia to chronic myelomonocytic leukemia as progression of myeloid neoplasm with platelet-derived growth factor ß rearrangement. Journal of Cancer Research and Therapeutics 11(4): 914-916, 2016

Comprehensive mutation profiling and mRNA expression analysis in atypical chronic myeloid leukemia in comparison with chronic myelomonocytic leukemia. Cancer Medicine 2019, 2019

A diagnostic dilemma: chronic myelomonocytic leukemia versus atypical chronic myeloid leukemia. A case report and review of the literature. Acta Haematologica 98(4): 221-227, 1997

A Diagnostic Dilemma: Chronic Myelomonocytic Leukemia versus Atypical Chronic Myeloid Leukemia. Acta Haematologica 98(4): 221-227, 2009

Chronic myelomonocytic leukemia and atypical chronic myeloid leukemia: novel pathogenetic lesions. Seminars in Oncology 39(1): 67-73, 2012

Recent Progress in Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia. Current Hematologic Malignancy Reports 12(5): 432-441, 2017

Stimulating capacity of leukemia cells from acute non-lymphocytic leukemia, chronic myelogenous leukemia, blastic crisis of chronic myelogenous leukemia, and chronic myelomonocytic leukemia in allogenic 'one way' mixed lymphocyte tumor cell reaction. Nihon Ketsueki Gakkai Zasshi 43(5): 796-804, 1980

The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood 106(10): 3377-3379, 2005

Prognostic significance of SETBP1 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia, and chronic neutrophilic leukemia: A meta-analysis. Plos One 12(2): E0171608, 2017

Clinical significance of CSF3R, SRSF2 and SETBP1 mutations in chronic neutrophilic leukemia and chronic myelomonocytic leukemia. Oncotarget 8(13): 20834-20841, 2017

A novel mutation of SETBP1 in atypical chronic myeloid leukemia transformed from acute myelomonocytic leukemia. Clinical Case Reports 3(6): 448-452, 2015

T618I-Mutated Colony Stimulating Factor 3 Receptor in Chronic Neutrophilic Leukemia and Chronic Myelomonocytic Leukemia Patients who Underwent Allogeneic Stem Cell Transplantation. Annals of Laboratory Medicine 35(3): 376-378, 2016