+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Nanoparticle-Loaded Protein-Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery



Nanoparticle-Loaded Protein-Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery



Advanced Materials 27(37): 5484-5492



A new formulation of volatile nanodroplets stabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058376809

Download citation: RISBibTeXText

PMID: 26265592

DOI: 10.1002/adma.201502022


Related references

Ultrasound-Enhanced siRNA Delivery Using Magnetic Nanoparticle-Loaded Chitosan-Deoxycholic Acid Nanodroplets. Advanced Healthcare Materials 6(8):, 2017

Drug-Loaded Perfluorocarbon Nanodroplets for Ultrasound-Mediated Drug Delivery. Advances in Experimental Medicine and Biology 880: 221-241, 2016

Estimating the delivery efficiency of drug-loaded microbubbles in cancer cells with ultrasound and bioluminescence imaging. Ultrasound in Medicine and Biology 38(11): 1938-1948, 2012

Focused ultrasound-facilitated brain drug delivery using optimized nanodroplets: vaporization efficiency dictates large molecular delivery. Physics in Medicine and Biology 63(3): 035002, 2018

Camptothecin-loaded fusogenic nanodroplets as ultrasound theranostic agent in stem cell-mediated drug-delivery system. Journal of Controlled Release 278: 100-109, 2018

Low-intensity focused ultrasound (LIFU)-activated nanodroplets as a theranostic agent for noninvasive cancer molecular imaging and drug delivery. Biomaterials Science 6(11): 2838-2849, 2018

Enhancing Macrophage Drug Delivery Efficiency via Co-Localization of Cells and Drug-Loaded Microcarriers in 3D Resonant Ultrasound Field. Plos one 10(8): E0135321, 2015

Drug-loaded and superparamagnetic iron oxide nanoparticle surface-embedded amphiphilic block copolymer micelles for integrated chemotherapeutic drug delivery and MR imaging. Langmuir 28(4): 2073-2082, 2012

Delivery of encapsulated Doxorubicin by ultrasound-mediated size reduction of drug-loaded polymer contrast agents. IEEE Transactions on Bio-Medical Engineering 57(1): 24-28, 2010

In situ preparation of gold nanoparticle-loaded lysozyme-dextran nanogels and applications for cell imaging and drug delivery. Nanoscale 5(7): 2892-2900, 2013

Nanoparticle-Coated Microbubbles for Combined Ultrasound Imaging and Drug Delivery. Langmuir 35(31): 10087-10096, 2019

Unibody core-shell smart polymer as a theranostic nanoparticle for drug delivery and MR imaging. Biomaterials 37: 436-446, 2015

Polymer-Stabilized Perfluorobutane Nanodroplets for Ultrasound Imaging Agents. Journal of the American Chemical Society 139(1): 15-18, 2017

Doxorubicin liposome-loaded microbubbles for contrast imaging and ultrasound-triggered drug delivery. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 60(1): 78-87, 2013

Synthesis, acoustic stability, and pharmacologic activities of papaverine-loaded echogenic liposomes for ultrasound controlled drug delivery. Journal of Liposome Research 18(4): 263-277, 2008