+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Nerve Ultrasound and Electrophysiology for Therapy Monitoring in Chronic Inflammatory Demyelinating Polyneuropathy



Nerve Ultrasound and Electrophysiology for Therapy Monitoring in Chronic Inflammatory Demyelinating Polyneuropathy



Journal of Neuroimaging 25(6): 931-939



We evaluated prospectively nerve ultrasound and electrophysiology as monitoring methods of intravenous immunoglobulin (IVIG) therapy in chronic inflammatory demyelinating polyneuropathy (CIDP). Overall 15 healthy subjects and 11 CIDP patients undergoing IVIG therapy were recruited in the study. All patients underwent clinical, ultrasound, and electrophysiological evaluation at the time point of first onset of symptoms (<6 weeks of symptoms) and 4, 8, and 12 months after onset. The intranerve cross-sectional area (CSA) variability of each nerve, but not the CSA alone, correlated with the MRC Scale score during 12-month follow-up. On the other hand, none of the electrophysiological parameters correlated with the MRC Scale Score in each of the peripheral nerves. Interestingly, in ¾ of the CIDP patients, the resolution of the conduction block correlated with the improvement in the MRC Sum score. Nerve ultrasound and in particular the intranerve CSA variability seems to be a useful method in monitoring CIDP patients. Although the sample size is small, the intranerve CSA variability seems to be more promising than neurophysiology.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058387585

Download citation: RISBibTeXText

PMID: 26242571

DOI: 10.1111/jon.12279


Related references

Nerve ultrasound can distinguish chronic inflammatory demyelinating polyneuropathy from demyelinating diabetic sensorimotor polyneuropathy. Journal of Clinical Neuroscience 57: 198-201, 2018

Can electrophysiology differentiate polyneuropathy with anti-MAG/SGPG antibodies from chronic inflammatory demyelinating polyneuropathy?. Clinical Neurophysiology 113(3): 346-353, 2002

Nerve echogenicity and intranerve CSA variability in high-resolution nerve ultrasound (HRUS) in chronic inflammatory demyelinating polyneuropathy (CIDP). Journal of Neurology 266(2): 468-475, 2019

Nerve ultrasound score in distinguishing chronic from acute inflammatory demyelinating polyneuropathy. Clinical Neurophysiology 125(3): 635-641, 2014

Correlation of nerve ultrasound, electrophysiological and clinical findings in chronic inflammatory demyelinating polyneuropathy. Journal of Neuroimaging 25(2): 207-216, 2015

Peripheral nerve block ultrasound guided in a patient with chronic inflammatory demyelinating polyneuropathy. Revista Espanola de Anestesiologia y Reanimacion 61(2): 113-114, 2014

Nerve ultrasound score in distinguishing chronic inflammatory demyelinating polyneuropathy from GuillainBarr syndrome. Journal of the Neurological Sciences 333: E442-E443, 2013

Nerve Ultrasound, Electrophysiological, and Clinical Changes in Treatment-Naive Chronic Inflammatory Demyelinating Polyneuropathy: A Case Report. Journal of Clinical Neurophysiology 36(1): 82-84, 2019

The value of sensory electrophysiology in chronic inflammatory demyelinating polyneuropathy. Clinical Neurophysiology 118(9): 1999-2004, 2007

Electrophysiology in chronic inflammatory demyelinating polyneuropathy with IGIV. Muscle and Nerve 39(4): 448-455, 2009

High-resolution nerve ultrasound and magnetic resonance neurography as complementary neuroimaging tools for chronic inflammatory demyelinating polyneuropathy. Therapeutic Advances in Neurological Disorders 11: 1756286418759974, 2018

Neuromuscular ultrasound findings in distal acquired demyelinating symmetric variant of chronic inflammatory demyelinating polyneuropathy. Muscle and Nerve 56(5): E44, 2017

Optimizing the use of electrophysiology in the diagnosis of chronic inflammatory demyelinating polyneuropathy: a study of 20 cases. Journal of the Peripheral Nervous System 10(3): 282-292, 2005

Mandibular nerve involvement in diabetic polyneuropathy and chronic inflammatory demyelinating polyneuropathy. Muscle and Nerve 21(12): 1673-1679, 1998

Rapid recovery of chronic inflammatory demyelinating polyneuropathy induced by steroid pulse therapy--changes in nerve conduction. Rinsho Shinkeigaku 33(2): 199-202, 1993