+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Neutrophilic-chronic myeloid leukemia: A case report



Neutrophilic-chronic myeloid leukemia: A case report



International Journal of Health Sciences 9(1): 87-90



Neutrophilic-chronic myelogenous leukemia (CML-N) is a rare chronic myelogenous leukemia (CML) variant characterized by BCR-ABL1 positive chronic neutrophilia. It has a BCR breakpoint on chromosome 22 between exons 17 and 20 in a region designated as micro-BCR. It is thought to have a more benign course than classical CML. This case report describes a 41-year-old Saudi woman diagnosed with CML-N. The peripheral blood and bone marrow picture for her were dominated by segmented neutrophils and fluorescent in situ hybridization was positive for BCR/ABL fusion of t(9;22). Our patient eventually required a stem cell transplant because of imatinib intolerance and bone marrow failure believed to be induced by nilotinib.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 058396677

Download citation: RISBibTeXText

PMID: 25901138


Related references

Specific molecular mutation patterns delineate chronic neutrophilic leukemia, atypical chronic myeloid leukemia, and chronic myelomonocytic leukemia. Haematologica 99(12): E244-E246, 2015

Neutrophilic pustulosis associated with chronic myeloid leukemia: a special form of Sweet's syndrome. Report of two cases. Acta Haematologica 88(2-3): 154-157, 1992

Molecular genetics of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia. Journal of Hematology and Oncology 7: 93, 2015

Febrile facial cellulitis: a severe and misleading case of acute neutrophilic skin disease in chronic myeloid leukemia. Annales de Dermatologie et de Venereologie 120(11): 803-805, 1993

Chronic neutrophilic leukemia: report of a case. Haematologica 71(2): 143-145, 1986

Chronic neutrophilic leukemia--a case report. Gaoxiong Yi Xue Ke Xue Za Zhi 11(3): 181-185, 1995

Chronic neutrophilic leukemia: a rare case report. Indian Journal of Hematology and Blood Transfusion 30(Suppl 1): 77-79, 2014

The occurrence of chronic lymphocytic leukemia after chronic phase of chronic myeloid leukemia: case report and literature review. Romanian Journal of Morphology and Embryology 56(3): 1145-1151, 2016

Recent Progress in Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia. Current Hematologic Malignancy Reports 12(5): 432-441, 2017

Molecular characterization of atypical chronic myeloid leukemia and chronic neutrophilic leukemia. Medicina Clinica 144(11): 487-490, 2016

Chronic neutrophilic leukemia--report of a case and review of the literature. Zhonghua Yi Xue Za Zhi 46(2): 109-112, 1990

Gaucher like cells in chronic neutrophilic leukemia a case report. Chinese Medical Journal (English Edition) 100(12): 988-989, 1987

Ruxolitinib for chronic neutrophilic leukemia: a case report and literature review. Zhonghua Xue Ye Xue Za Zhi 39(12): 1029-1032, 2019

Polycythemia vera terminating in chronic neutrophilic leukemia: report of a case. American Journal of Hematology 35(2): 139-140, 1990

Chronic neutrophilic leukemia: case report documenting the absence of bcr-abl rearrangement. American Journal of Hematology 41(4): 304, 1992