+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

New Clues that May Link Osteoporosis to the Circulating Lipid Profile



New Clues that May Link Osteoporosis to the Circulating Lipid Profile



Bone Research 1(3): 260-266



Bone Mineral Density (BMD) is a gold standard for the diagnosis of osteoporosis and is also important in the assessment of fracture risk. Other risk factors have been identified that together make up fracture risk assessment tools such as FRAX. Another potential factor, circulating lipids, has been suggested because of reports linking statins to fracture risk reduction. We analyzed the lipid profile in a cohort of women diagnosed with postmenopausal osteoporosis based on bone density determination: 610 women with osteoporosis (mean lumbar spine T-score -3.16±0.81, mean yrs. since menopause 15.79±8.9) were grouped according to age at evaluation (< 50 years, 51-60 years, 61-70 years, > 70 years), the presence/absence of a history of a fragility fracture, statin and/or antiresorptive drug use. There was no correlation between BMD and Body Mass Index (BMI: P>0.05, r (2)<0.02). However, when BMD was correlated with both BMI and the lipid profile (Triglycerides, Cholesterol, LDLc, HDLc), significant correlations were found in 5 cohorts: 51-60 years with fractures (n=61, r (2)=0.14, P<0.01), 61-70 years (n=201, r (2)=0.09, P<0.01) with fractures (n=88, r (2)=0.14, P<0.01) or without fractures (n=113, r (2)=0.24, P=0.02) and over 70 years (n=247, r (2)=0.11, P<0.01).

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058397315

Download citation: RISBibTeXText

PMID: 26273507

DOI: 10.4248/BR201303004


Related references

Anorexia nervosa, osteoporosis and circulating leptin: the missing link. Osteoporosis International 21(10): 1715-1722, 2011

Lipid levels: a link between cardiovascular disease and osteoporosis?. Journal of Bone and Mineral Research 24(6): 1103-1109, 2009

Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporosis International 16(10): 1263-1271, 2005

Serum lipid profile in postmenopausal women with osteoporosis or osteopenia. Southern Medical Journal 99(1): 95-96, 2006

Association between lipid profile and circulating concentrations of estrogens in young men. Atherosclerosis 203(1): 257-262, 2008

Circulating Betatrophin Levels Are Associated with the Lipid Profile in Type 2 Diabetes. Chonnam Medical Journal 51(3): 115-119, 2016

Serum amyloid a gene polymorphism and its association with lipid profile in Saudi females with osteoporosis. Pakistan Journal of Medical Sciences 31(5): 1124-1129, 2015

Circulating Irisin Concentrations Are Associated with a Favourable Lipid Profile in the General Population. Plos One 11(4): E0154319-E0154319, 2016

Transdermal estrogen therapy improves lipid profile and osteoporosis in postmenopausal liver transplant patients. Transplantation Proceedings 33(1-2): 1472-1473, 2001

Is leptin associated with serum lipid profile or any other parameters of blood biochemistry in post-menopausal women with osteoporosis?. Journal of International Medical Research 32(4): 359-366, 2004

Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokines. European Journal of Endocrinology 154(1): 83-86, 2005

The circulating PBEF/NAMPT/visfatin level is associated with a beneficial blood lipid profile. Pflugers Archiv 454(6): 971-976, 2007

Status of circulating lipid profile in human uterine cervical carcinoma before and after therapy. Journal of Clinical Biochemistry & Nutrition 21(3): 219-225, 1996

Plasma Clusterin and Lipid Profile: A Link with Aging and Cardiovascular Diseases in a Population with a Consistent Number of Centenarians. Plos One 10(6): E0128029-E0128029, 2016

Association of circulating irisin levels with normal weight obesity, glycemic and lipid profile. Journal of Diabetes and Metabolic Disorders 15: 17-17, 2015