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New Diagnostic Tools for Neonatal Sepsis: The Role of a Real-Time Polymerase Chain Reaction for the Early Detection and Identification of Bacterial and Fungal Species in Blood Samples



New Diagnostic Tools for Neonatal Sepsis: The Role of a Real-Time Polymerase Chain Reaction for the Early Detection and Identification of Bacterial and Fungal Species in Blood Samples



Journal of ChemoTherapy 19(Sup 2): 31-34



NlmCategory="UNASSIGNED">Early diagnosis and treatment of neonatal sepsis are essential to prevent severe and life threatening complications. Consequently, rapid diagnostic tests capable to differentiate infected from non-infected newborns have the potential to make a significant impact on neonatal care. A new real-time polymerase chain reaction (PCR; LightCycler® SeptiFast test MGRADE) has been proposed in the routine assessment of neonatal sepsis for the detection and identification of bacterial and fungal DNA from microorganisms which cause approximately 90% of all blood stream infections. The LightCycler® SeptiFast test can detect and identify simultaneously the 25 most important bacterial and fungal species causing bloodstream infections within few hours by using a small volume of a single whole blood sample. Real-time PCR can be easily incorporated into the hospital setting for term or near-term infants admitted to the neonatal intensive care unit for sepsis evaluation.

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Accession: 058397471

Download citation: RISBibTeXText

PMID: 27796230

DOI: 10.1080/1120009x.2007.11782441


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