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Nickel- and Photoredox-Catalyzed Cross-Coupling Reactions of Aryl Halides with 4-Alkyl-1,4-dihydropyridines as Formal Nucleophilic Alkylation Reagents

Nakajima, K.; Nojima, S.; Nishibayashi, Y.

Angewandte Chemie 55(45): 14106-14110

2016

ISSN/ISBN: 1521-3773
PMID: 27709775
DOI: 10.1002/anie.201606513
Accession: 058408179
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A combination of nickel and photoredox catalysts promoted novel cross-coupling reactions of aryl halides with 4-alkyl-1,4-dihydropyridines. 4-Alkyl-1,4-dihydropyridines act as formal nucleophilic alkylation reagents through a photoredox-catalyzed carbon-carbon (C-C) bond-cleavage process. The present strategy provides an alternative to classical carbon-centered nucleophiles, such as organometallic reagents.

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