+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients

Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma: A Retrospective Multicenter Study in 2653 Patients

Medicine 94(36): E1433

The objective of this study was to analyze different types of nodal basin recurrence after sentinel lymph node biopsy (SLNB) for melanoma. Kaplan-Meier estimates and the Cox proportional hazards model were used to study 2653 patients from 3 German melanoma centers retrospectively.The estimated 5-year negative predictive value of SLNB was 96.4%. The estimated false-negative (FN) rates after 1, 2, 3, 5, and 10 years were 2.5%, 4.6%, 6.4%, 8.7%, and 12.6%, respectively. Independent factors associated with false negativity were older age, fewer SLNs excised, and head or neck location of the primary tumor. Compared with SLN-positive patients, the FNs had a significantly lower survival. In SLN-positive patients undergoing completion lymphadenectomy (CLND), the 5-year nodal basin recurrence rate was 18.3%. The recurrence rates for axilla, groin, and neck were 17.2%, 15.5%, and 44.1%, respectively. Significant factors predicting local relapse after CLND were older age, head, or neck location of the primary tumor, ulceration, deeper penetration of the metastasis into the SLN, tumor-positive CLND, and >2 lymph node metastases. All kinds of nodal relapse were associated with a higher prevalence of in-transit metastases.The FN rate after SLNB steadily increases over the observation period and should, therefore, be estimated by the Kaplan-Meier method. False-negativity is associated with fewer SLNs excised. The beneficial effect of CLND on nodal basin disease control varies considerably across different risk groups. This should be kept in mind about SLN-positive patients when individual decisions on prophylactic CLND are taken.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 058412561

Download citation: RISBibTeXText

PMID: 26356697

DOI: 10.1097/md.0000000000001433

Related references

The benefit of a sentinel lymph node biopsy and adjuvant therapy in thick (>4 mm) melanoma: multicenter, retrospective study of 291 Japanese patients. Melanoma Research 22(5): 362-367, 2012

Regional nodal basin control is not compromised by previous sentinel lymph node biopsy in patients with melanoma. Annals of Surgical Oncology 7(3): 226-231, 2000

Surgical management of sentinel lymph node biopsy outside major nodal basin in patients with cutaneous melanoma. Annals of Surgical Oncology 21(1): 300-305, 2014

Pathologic review of negative sentinel lymph nodes in melanoma patients with regional recurrence: a clinicopathologic study of 1152 patients undergoing sentinel lymph node biopsy. American Journal of Surgical Pathology 27(9): 1197-1202, 2003

Significance of multiple nodal basin drainage in truncal melanoma patients undergoing sentinel lymph node biopsy. Annals of Surgical Oncology 7(4): 256-261, 2000

Multicenter Selective Lymphadenectomy Trial-I confirms the central role of sentinel node biopsy in contemporary melanoma management: response to 'No survival benefit for patients with melanoma undergoing sentinel lymph node biopsy: critical appraisal of the Multicenter Selective Lymphadenectomy Trial-I final report'. British Journal of Dermatology 172(3): 571-573, 2015

Sentinel lymph node biopsy for early cervical cancer: Results of a randomized prospective, multicenter study (Senticol 2) comparing adding pelvic lymph node dissection vs sentinel node biopsy only. Gynecologic Oncology 145: 2-3, 2017

Complications associated with sentinel lymph node biopsy for cutaneous melanoma. A retrospective study of 127 patients. Annales de Chirurgie Plastique et Esthetique 57(2): 151-157, 2012

Prognostic Role of Multiple Lymphatic Basin Drainage in Sentinel Lymph Node-Negative Trunk Melanoma Patients: A Multicenter Study from the Italian Melanoma Intergroup. Annals of Surgical Oncology 23(5): 1708-1715, 2016

Sentinel lymph node biopsy or nodal observation in melanoma: study of an Italian series. Giornale Italiano di Dermatologia e Venereologia 148(3): 299-305, 2013

Patterns of First-Recurrence and Post-Recurrence Survival in Patients with Primary Cutaneous Melanoma After Sentinel Lymph Node Biopsy. Yearbook of Dermatology and Dermatologic Surgery 2009: 416-417, 2009

Patterns of first-recurrence and post-recurrence survival in patients with primary cutaneous melanoma after sentinel lymph node biopsy. Annals of Surgical Oncology 14(6): 1934-1942, 2007

Comparison between F-Fluorodeoxyglucose Positron Emission Tomography and Sentinel Lymph Node Biopsy for Regional Lymph Nodal Staging in Patients with Melanoma: A Review of the Literature. Radiology Research and Practice 2011: 912504, 2011

False-negative sentinel lymph node biopsy resulting from obstruction of lymphatic basin by nodal metastasis: a case report of malignant melanoma. Journal of Dermatology 38(11): 1121-1124, 2011

Sentinel lymph node biopsy in patients with thin melanoma: occurrence of nodal metastases and its prognostic value. European Journal of Dermatology 20(1): 30-34, 2010