Non-inferiority of pulsed xenon ultraviolet light versus bleach versus for reducing environmental Clostridium difficile contamination on high-touch surfaces in Clostridium difficile isolation rooms

Ghantoji, S.S.; Stibich, M.; Stachowiak, J.; Cantu, S.; Adachi, J.A.; Raad, I.I.; Chemaly, R.

Journal of Medical Microbiology (): -


ISSN/ISBN: 0022-2615
PMID: 25587076
Accession: 058415160

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NlmCategory="UNASSIGNED">In patients with malignancy, the major barrier to achieving complete response is emergence of resistance to current chemotherapeutic agents. One of the major mechanisms by which tumor cells become resistant to therapies is by altering cellular drug targets through mutations and/or deletions. Resistance by this mechanism is achieved more easily if the drug has limited cellular targets and/or processes. We hypothesized that since Pseudomonas aeruginosa ExoT targets six proteins that are required for cancer cell survival and proliferation, it is highly unlikely for cancer cells to develop resistance to this toxin. We assessed ExoT's cytotoxicity against multiple invasive and highly resistant tumor cell lines in order to evaluate its potential as a chemotherapeutic agent. Our data demonstrate that ExoT induces potent cytotoxicity in all tumor cell lines that we examined. Collectively, our data highlights the potential of ExoT as a possible chemotherapeutic candidate for the treatment of cancer.