+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Disease Activity of Juvenile Idiopathic Arthritis during and after Pregnancy: A Prospective Multicenter Study

Disease Activity of Juvenile Idiopathic Arthritis during and after Pregnancy: A Prospective Multicenter Study

Journal of Rheumatology 45(2): 257-265

To study disease activity in women with juvenile idiopathic arthritis (JIA) during and after pregnancy. There is little previous knowledge about this topic. Our study included 135 pregnancies in 114 women with JIA. Disease activity was assessed at 7 timepoints before, throughout, and after pregnancy with the Disease Activity Score-28-C-reactive protein 3 (DAS28-CRP3). Scores assessed at each visit were analyzed in a linear mixed model. The same statistical method was used to study self-reported physical function, pain, and mental health. Almost 80% of the women were in remission or had low disease activity during and after pregnancy. Although disease activity was stable throughout the study period, we found that DAS28 6 weeks postpartum increased significantly compared to the first trimester (2.78 vs 2.51, p = 0.005) and third trimester (2.78 vs 2.56, p = 0.011), respectively. DAS28 decreased significantly between 6 weeks and 12 months postpartum (2.78 vs 2.54, p = 0.014). Self-reported mental health was significantly better 6 weeks postpartum than before pregnancy (Medical Outcomes Study Short Form-36 Mental Health subscale 80.7 vs 76.5, p = 0.039). Self-reported pain was stable. Physical function was significantly worse in the third trimester of pregnancy than postpartum (Modified Health Assessment Questionnaire 0.57 vs 0.39, p < 0.001). In women with JIA, disease activity was highest 6 weeks postpartum, but altogether low and stable in the period from planning pregnancy to 1 year after delivery.

(PDF emailed within 0-6 h: $19.90)

Accession: 058427199

Download citation: RISBibTeXText

PMID: 29196380

DOI: 10.3899/jrheum.161410

Related references

Interpretation of the Juvenile Arthritis Disease Activity Score: responsiveness, clinically important differences and levels of disease activity in prospective cohorts of patients with juvenile idiopathic arthritis. Rheumatology 53(2): 307-312, 2014

Disease activity and disability in children with juvenile idiopathic arthritis one year following presentation to paediatric rheumatology. Results from the Childhood Arthritis Prospective Study. Rheumatology 49(1): 116-122, 2010

Disease activity of psoriatic arthritis during and after pregnancy: A prospective multicenter study. Arthritis Care and Research 2018, 2018

Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: results of a Canadian multicenter, prospective inception cohort study. Arthritis and Rheumatism 61(8): 1077-1086, 2009

Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with Juvenile Idiopathic Arthritis: results from the childhood arthritis prospective Study. Rheumatology 55(7): 1225-1234, 2017

AB0901 Trends in Paediatric Rheumatology Referral Times and Disease Activity Indices over A Ten-Year Period among Children with Juvenile Idiopathic Arthritis: Results from the Childhood Arthritis Prospective Study (CAPS). Annals of the Rheumatic Diseases 73(Suppl 2): 1098-1099, 2014

Association of disease activity and anti-rheumatic treatment in juvenile idiopathic arthritis with serum lipid profiles: a prospective study. Seminars in Arthritis and Rheumatism 42(6): 590-596, 2014

Analysis of disease activity, functional disability and articular damage in patients with juvenile idiopathic arthritis: a prospective outcome study. Clinical and Experimental Rheumatology 29(2): 337-344, 2011

AB0679Analysis of disease activity, functional disability and articular damage in patients with juvenile idiopathic arthritis: a prospective outcome study. Annals of the Rheumatic Diseases 72(Suppl 3): A995.4-A995, 2013

Finding specific 10-joint Juvenile Arthritis Disease Activity Score (JADAS10) and clinical JADAS10 cut-off values for disease activity levels in non-systemic juvenile idiopathic arthritis: a Finnish multicentre study. Rheumatology 55(4): 615-623, 2016

Hormonal alterations and disease activity during pregnancy in systemic lupus erythematosus in comparison with rheumatoid arthritis and juvenile idiopathic arthritis. 2006

A prospective study comparing infection risk and disease activity in children with juvenile idiopathic arthritis treated with and without tumor necrosis factor-alpha inhibitors. Clinical Rheumatology 34(3): 457-464, 2015

Juvenile idiopathic arthritis and future risk for cardiovascular disease: a multicenter study. Scandinavian Journal of Rheumatology 45(4): 299-303, 2017

Remission, minimal disease activity, and acceptable symptom state in juvenile idiopathic arthritis: defining criteria based on the juvenile arthritis disease activity score. Arthritis and Rheumatism 64(7): 2366-2374, 2012

A multicenter study of patients with adult-onset Still's disease compared with systemic juvenile idiopathic arthritis. Clinical Rheumatology 25(5): 639-644, 2005