+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Disruption of female reproductive function by endotoxins



Disruption of female reproductive function by endotoxins



Reproduction 155(4): R169



Endotoxemia can be caused by obesity, environmental chemical exposure, abiotic stressors and bacterial infection. Circumstances that deleteriously impact intestinal barrier integrity can induce endotoxemia, and controlled experiments have identified negative impacts of lipopolysaccharide (LPS; an endotoxin mimetic) on folliculogenesis, puberty onset, estrus behavior, ovulation, meiotic competence, luteal function and ovarian steroidogenesis. In addition, neonatal LPS exposures have transgenerational female reproductive impacts, raising concern about early life contacts to this endogenous reproductive toxicant. Aims of this review are to identify physiological stressors causing endotoxemia, to highlight potential mechanism(s) by which LPS compromises female reproduction and identify knowledge gaps regarding how acute and/or metabolic endotoxemia influence(s) female reproduction.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058455139

Download citation: RISBibTeXText

PMID: 29363567

DOI: 10.1530/rep-17-0406


Related references

Disruption of the tissue inhibitor of metalloproteinase-1 gene results in altered reproductive cyclicity and uterine morphology in reproductive-age female mice. Biology of Reproduction 63(3): 905-912, 2000

Some aspects of endotoxins on luteal function in female goats. 10th International Congress on Animal Reproduction and Artificial Insemination University of Illinois at Urbana Champaign Illinois USDA June 10-14-1984, 1984

Prenatal programming of reproductive neuroendocrine function: fetal androgen exposure produces progressive disruption of reproductive cycles in sheep. Endocrinology 144(4): 1426-1434, 2003

Endocrine aspects of testicular function, especially hormones in the seminal plasma and their fate in the female reproductive tract: testicular steroids and their relevance for male and female reproductive functions. Boar semen preservation II Proceedings of the Second International Conference on Boar Semen Preservation held at Beltsville, Maryland, USA, August 1990: 41-61, 1991

Disruption of the female reproductive system by the phytoestrogen genistein. Reproductive Toxicology 23(3): 308-316, 2007

Peripheral effects of prolactin in reproductive function. II. Female reproductive function. Journal de Gynecologie Obstetrique et Biologie de la Reproduction 18(3): 288-294, 1989

The peripheral effects of prolactin in reproductive function ii female reproductive function. Journal de Gynecologie Obstetrique et biologie de la Reproduction 18(3): 288-294, 1989

Disruption of the developing female reproductive system by phytoestrogens: genistein as an example. Molecular Nutrition and Food Research 51(7): 832-844, 2007

Disruption of the upper female reproductive tract epithelium by nonoxynol-9. Contraception 68(4): 273-279, 2003

Reproductive senescence in female rats no evidence for disruption of circadian rhythms. Society for Neuroscience Abstracts 12(2): 1070, 1986

Wnt genes and endocrine disruption of the female reproductive tract: A genetic approach. Molecular and Cellular Endocrinology 158(1-2): 1-5, 1999

Wnt genes and endocrine disruption of the female reproductive tract: a genetic approach. Molecular and Cellular Endocrinology 158(1-2): 1-5, 1999

Endocrine disruption of oestrogen action and female reproductive tract cancers. Endocrine-RelatedCancer21(2):T13, 2014

Lead disruption of reproductive capacity occurs in an analogous fashion in the male and female axes. Clinical Research 42(1): 73A, 1994

Disruption of the TIMP-1 gene product induces uterine anomalies in reproductive age female mice. Biology of Reproduction 62(Suppl. 1): 116, 2000