+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Optic Disc Hemorrhages and Laminar Disinsertions in Glaucoma



Optic Disc Hemorrhages and Laminar Disinsertions in Glaucoma



Ophthalmology 123(9): 1949-1956



To determine whether structural abnormalities of the lamina cribrosa explain the presence of optic disc hemorrhages, we determined the spatial concordance between disc hemorrhages and laminar disinsertions from the sclera. Prospective noninterventional study. From open-angle glaucoma patients followed up prospectively, we identified 52 eyes of 46 open-angle glaucoma patients with optic disc hemorrhage (ODH+ group) in at least 1 optic disc photograph during follow-up. We also identified 52 control eyes of 46 glaucoma patients in whom no disc hemorrhage was detected (ODH- group). Enhanced depth imaging optical coherence tomography of the optic nerve head (24 radial scans) was performed. The scans were de-identified and a trained observer masked to all clinical information determined the presence of laminar disinsertions in each of the 48 positions with a confidence score of 1 (least certain) to 5 (most certain). Only disinsertions with a score of 3 or more were included in the analysis. Frequency and spatial concordance between disc hemorrhages and laminar disinsertions. The median age, visual field mean deviation, and follow-up period of the ODH+ and ODH- groups was 77.5 and 70.8 years, -5.20 and -4.70 dB, and 10.4 and 9.9 years, respectively. There were 84 hemorrhages recorded in the ODH+ group. There were laminar disinsertions in 50 eyes (96%) in the ODH+ group and in 27 eyes (52%) in the ODH- group, with 2 or more disinsertions in 30 eyes (58%) and 5 eyes (10%), respectively. Most hemorrhages and disinsertions were located in the inferotemporal and superotemporal sectors. However, in individual patients, only 33 of the ODHs (39%) were located within a laminar disinsertion. Laminar disinsertions occurred twice as frequently in eyes with ODHs; however, in individual patients, the spatial concordance between ODHs and laminar disinsertions was poor.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058464376

Download citation: RISBibTeXText

PMID: 27432205

DOI: 10.1016/j.ophtha.2016.06.001


Related references

Optic disc hemorrhages in glaucoma. Investigative Ophthalmology and Visual Science 38(4 Part 1-2): S249, 1997

The significance of optic disc hemorrhages in glaucoma. Journal of Glaucoma 6(1): 62-64, 1997

Factors associated with optic disc hemorrhages in glaucoma. Ophthalmology 111(9): 1653-1657, 2004

Optic disc hemorrhages and progression of glaucoma. Ophthalmology. 103(7): 1014-1024, 1996

Optic disc hemorrhages preceding manifest glaucoma. Acta Ophthalmologica 68(4): 450-454, 1990

Optic disc hemorrhages in a population with and without signs of glaucoma. Ophthalmology. 105(2): 216-223,., 1998

Optic disc hemorrhages in glaucoma and common clinical features. Canadian Journal of Ophthalmology. Journal Canadien d'Ophtalmologie 52(6): 583-591, 2017

Deterioration of visual fields in patients with glaucoma with and without optic disc hemorrhages. Archives of Ophthalmology 115(10): 1257-1262, 1997

Morphologic predictive factors for development of optic disc hemorrhages in glaucoma. Investigative Ophthalmology and Visual Science 43(9): 2956-2961, 2002

Optic disc hemorrhages in glaucoma and ocular hypertension: implications and recommendations. Current Opinion in Ophthalmology 19(2): 89-94, 2008

Morphologic Predictive Factors for the Development of Optic Disc Hemorrhages in Glaucoma. ARVO Annual Meeting Abstract Search and Program Planner : Abstract No 926, 2002

Association between optic disc hemorrhages in glaucoma and abnormal glucose tolerance. British Journal of Ophthalmology 70(8): 599-602, 1986

Structural Differences in the Optic Nerve Head of Glaucoma Patients With and Without Disc Hemorrhages. Journal of Glaucoma 25(2): E76, 2016

Follow-up examination of eyes with chronic open-angle glaucoma and optic disc hemorrhages. Der Ophthalmologe 101(5): 505-508, 2004

Factors associated with optic disc hemorrhages in a longitudinal study of patients with open angle glaucoma. ARVO Annual Meeting Abstract Search and Program Planner : Abstract No 99, 2003