+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Optimizing the calculation of DM,CO and VC via the single breath single oxygen tension DLCO/NO method

Optimizing the calculation of DM,CO and VC via the single breath single oxygen tension DLCO/NO method

Respiratory Physiology and Neurobiology 221: 19-29

Alveolar-capillary membrane conductance (D(M,CO)) and pulmonary-capillary blood volume (V(C)) are calculated via lung diffusing capacity for carbon monoxide (DL(CO)) and nitric oxide (DL(NO)) using the single breath, single oxygen tension (single-FiO2) method. However, two calculation parameters, the reaction rate of carbon monoxide with blood (θ(CO)) and the D(M,NO)/D(M,CO) ratio (α-ratio), are controversial. This study systematically determined optimal θ(CO) and α-ratio values to be used in the single-FiO2 method that yielded the most similar D(M,CO) and V(C) values compared to the 'gold-standard' multiple-FiO2 method. Eleven healthy subjects performed single breath DL(CO)/DL(NO) maneuvers at rest and during exercise. D(M,CO) and V(C) were calculated via the single-FiO2 and multiple-FiO2 methods by implementing seven θ(CO) equations and a range of previously reported α-ratios. The RP θ(CO) equation (Reeves, R.B., Park, H.K., 1992. Respiration Physiology 88 1-21) and an α-ratio of 4.0-4.4 yielded DM,CO and VC values that were most similar between methods. The RP θ(CO) equation and an experimental α-ratio should be used in future studies.

(PDF emailed within 0-6 h: $19.90)

Accession: 058470130

Download citation: RISBibTeXText

PMID: 26521031

DOI: 10.1016/j.resp.2015.10.016

Related references

A modified single-breath DLCO apparatus. Respiratory Therapy 14(2): 63-65, 1984

Standardization of spirometry and single breath DLCO tests. European Respiratory Journal 1(4): 293-296, 1988

Effect of preinspiratory maneuver on the single-breath DLCO. American Journal of Respiratory and Critical Care Medicine 152(2): 804-807, 1995

Effect of alveolar volume on the interpretation of single breath DLCO. Respiratory Medicine. 91(5): 263-273, 1997

Computer control aspects of a single breath DLCO station. Biomedical Sciences Instrumentation 18: 121-130, 1982

Single-breath DLCO maneuver causes cardiac output to fall during and after cycling. Journal of Applied Physiology 65(1): 41-45, 1988

Effects of inspiratory and expiratory time and high mouth pressures on calculated DLCO by the single-breath procedure. Results with different methods to measure the effective breath-holding time. Respiration; International Review of Thoracic Diseases 57(4): 280-285, 1990

Investigation of computer lung model-predicted DLCO during single-breath maneuvers. Journal of Applied Physiology 76(5): 2210-2215, 1994

Effect of cold pressor test on single-breath DLCO in normal subjects. Journal of Applied Physiology 76(2): 750-755, 1994

Disappearance curves and single-breath DLCO from consecutive samples during slow expiration. Tohoku Journal of Experimental Medicine 136(4): 419-431, 1982

A multislice single breath-hold scheme for imaging alveolar oxygen tension in humans. Magnetic Resonance in Medicine 67(5): 1332-1345, 2012

The relationship between alveolar oxygen tension and the single-breath carbon monoxide diffusing capacity. American Review of Respiratory Disease 133(4): 676-678, 1986

Of the need to reconcile discrepancies between two different reference equations on combined single-breath DLNO-DLCO in systemic sclerosis. European Respiratory Journal 2019, 2019

Genome-Wide Association Analysis of Single Breath Diffusing Capacity of Carbon Monoxide (DLCO). American Journal of Respiratory Cell and Molecular Biology 2019, 2019

Significance of isolated reduction in single breath diffusing capacity dlco in men and women with complaints of exertional dyspnea. American Review of Respiratory Disease 143(4 PART 2): A172, 1991