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Overall quality of life (QoL) is not meaningfully affected by severity of pegylated liposomal doxorubicin (PLD)-associated palmar-plantar erythrodysesthesia (PPE) among women with metastatic breast cancer



Overall quality of life (QoL) is not meaningfully affected by severity of pegylated liposomal doxorubicin (PLD)-associated palmar-plantar erythrodysesthesia (PPE) among women with metastatic breast cancer



Journal of Clinical Oncology 23(16_Suppl): 788-788



NlmCategory="UNASSIGNED">788 Background: Chemotherapy-associated toxicities such as anemia and neurotoxicity are evaluated using toxicity-specific instruments such as the FACT-AN and the FACT-NTX. PLD is a new chemotherapeutic agent demonstrated clinical efficacy in metastatic breast cancer both as a first-line agent (O'Brien Ann of Oncology 2004) and for taxane-refractory disease (Keller JCO 2004). Its most common toxicity is PPE (rates of severe [Grade 3-4] toxicity: 17% and 19%, respectively). We evaluated the utility of a commonly used QOL instrument to evaluate PPE impact among metastatic breast cancer patients who participated in recent RCTs with PLD. All PLD-treated patients in the first-line (n=150) and taxane-refractory (n=254) RCTs completed a general cancer-related QOL instrument, the European Organization for Research and Treatment of Cancer QLQ-30 at baseline and prior to subsequent chemotherapy cycles with PLD during the course of the trial. Mean QLQ-30 scores for PLD-treated patients (1st line and taxane-refractory RCTs) were similar regardless of whether the patient developed severe PPE or not at all. (Table 1, *p<0.05) Conclusions: PPE does not appear to meaningfully impact overall patient reported QoL. Further research is needed to determine if a syndrome specific questionnaire for PLD-associated PPE is needed. [Figure: see text] [Table: see text].

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Accession: 058484974

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PMID: 27945760


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