+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Ox40L-Ox40 pathway plays distinct roles in regulating Th2 responses but does not determine outcome of cutaneous leishmaniasis caused by Leishmania mexicana and Leishmania major



Ox40L-Ox40 pathway plays distinct roles in regulating Th2 responses but does not determine outcome of cutaneous leishmaniasis caused by Leishmania mexicana and Leishmania major



Experimental Parasitology 148: 49-55



Ox40 ligand (Ox40L)-Ox40 pathway has been shown to enhance Th2 responses and play a role in pathogenesis of cutaneous leishmaniasis (CL) caused by Leishmania major. Using Ox40l(-/-) BALB/c mice we analyzed the role of this pathway in determining the outcome to CL caused by L. mexicana and compared to L. major. Contrary to our expectations, Ox40l(-/-) mice were highly susceptible to both L. major (LV39) and L. mexicana (M379) and developed large non-healing lesions containing parasites comparable to Ox40l(+/+) BALB/c mice. Interestingly, upon in vitro stimulation with Leishmania antigen (LmAg), the lymph node cells from L. major infected Ox40l(-/-) mice produced significantly less IL-4 and IL-10 compared to Ox40l(+/+) mice. L. mexicana infected Ox40l(-/-) and Ox40l(+/+) mice did not show any difference in the production of IL-4 and IL-10. No difference was noted in the amount of Th1 cytokines IFN-ү and IL-12 produced by Ox40l(-/-) and Ox40l(+/+) mice infected with either parasite. These results indicate that the Ox40L-Ox40 pathway promotes Th2 bias only in L. major infection but not L. mexicana infection and this pathway is not critical for susceptibility to CL.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 058487931

Download citation: RISBibTeXText

PMID: 25447125

DOI: 10.1016/j.exppara.2014.11.002


Related references

Draft Genome Sequences of Leishmania ( Leishmania ) amazonensis , Leishmania ( Leishmania ) mexicana , and Leishmania ( Leishmania ) aethiopica , Potential Etiological Agents of Diffuse Cutaneous Leishmaniasis. Microbiology Resource Announcements 8(20):, 2019

Molecular karyotype characterization of Leishmania panamensis, Leishmania mexicana, and Leishmania major-like parasites: agents of cutaneous leishmaniasis in Ecuador. American Journal of Tropical Medicine and Hygiene 48(5): 707-715, 1993

Relapse of new world diffuse cutaneous leishmaniasis caused by Leishmania (Leishmania) mexicana after miltefosine treatment. American Journal of Tropical Medicine and Hygiene 75(6): 1074-1077, 2006

Andean leishmaniasis in ecuador caused by infection with leishmania mexicana and leishmania major like parasites. American Journal of Tropical Medicine & Hygiene 44(2): 205-217, 1991

The experimental chemo therapy of leishmaniasis 6. the development of rodent models for cutaneous infection with leishmania major and leishmania mexicana amazonensis. Annals of Tropical Medicine and Parasitology 74(3): 299-320, 1980

Differences in Lsh gene control over systemic Leishmania major and Leishmania donovani or Leishmania mexicana mexicana infections are caused by differential targeting to infiltrating and resident liver macrophage populations. Infection and Immunity 56(5): 1128-1134, 1988

Experimental cutaneous leishmaniasis. 3. Comparative pathology of infection by Leishmania brazilensis, Leishmania mexicana, and Leishmania tropica in laboratory animals. Revista do Instituto de Medicina Tropical de Sao Paulo 14(1): 12-29, 1972

Inbred mice as model hosts for cutaneous leishmaniasis 1. resistance and susceptibility to infection with leishmania braziliensis leishmania mexicana and leishmania aethiopica. Annals of Tropical Medicine and Parasitology 78(1): 25-34, 1984

Cutaneous leishmaniasis in Amazonia. Report of the 1st human case of mixed infection, determined by 2 different Leishmania species: Leishmania brasiliensis and Leishmania mexicana amazonensis. Revista do Instituto de Medicina Tropical de Sao Paulo 26(5): 272-275, 1984

Immunoregulatory pathways in murine leishmaniasis: different regulatory control during Leishmania mexicana mexicana and Leishmania major infections. Clinical and Experimental Immunology 61(3): 674-682, 1985

The experimental chemo therapy of leishmaniasis 7. drug responses of leishmania major and leishmania mexicana amazonensis with an analysis of promising chemical leads to new anti leishmanial agents. Annals of Tropical Medicine and Parasitology 74(3): 321-336, 1980

Treatment of two patients with diffuse cutaneous leishmaniasis caused by Leishmania mexicana modifies the immunohistological profile but not the disease outcome. Tropical Medicine and International Health 4(12): 801-811, 1999

Preliminary study towards a novel experimental model to study localized cutaneous leishmaniasis caused by Leishmania (Leishmania) mexicana. Revista do Instituto de Medicina Tropical de Sao Paulo 54(3): 165-169, 2012

Effect of Leishmania gerbilli injection on mice immunization against cutaneous leishmaniasis (CL) caused by Leishmania major. Pakistan Journal of Biological Sciences 10(1): 196-198, 2007

EAPB0503: An Imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica. Plos Neglected Tropical Diseases 12(11): E0006854, 2018