+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Oxidant and enzymatic antioxidant status (gene expression and activity) in the brain of chickens with cold-induced pulmonary hypertension



Oxidant and enzymatic antioxidant status (gene expression and activity) in the brain of chickens with cold-induced pulmonary hypertension



International Journal of Biometeorology 59(11): 1615-1621



To evaluate oxidant and antioxidant status of the brain (hindbrain, midbrain, and forebrain) in chickens with cold-induced pulmonary hypertension, the measurements of lipid peroxidation, protein oxidation, antioxidant capacity, enzymatic activity, and gene expression (for catalase, glutathione peroxidase, and superoxide dismutases) were done. There were high lipid peroxidation/protein oxidation and low antioxidant capacity in the hindbrain of cold-induced pulmonary hypertensive chickens compared to control (Pā€‰<ā€‰0.05). In the hypertensive chickens, superoxide dismutase activity was decreased (forebrain, midbrain, and hindbrain), while catalase activity was increased (forebrain and midbrain) (Pā€‰<ā€‰0.05). Glutathione peroxidase activity did not change. Relative gene expression of catalase and superoxide dismutases (1 and 2) was downregulated, while glutathione peroxidase was upregulated in the brain of the cold-induced pulmonary hypertensive chickens. Probably, these situations in the oxidant and antioxidant status of the brain especially hindbrain may change its function at cardiovascular center and sympathetic nervous system to exacerbate pulmonary hypertension.

(PDF emailed within 0-6 h: $19.90)

Accession: 058488143

Download citation: RISBibTeXText

PMID: 25939899

DOI: 10.1007/s00484-015-0968-z


Related references

Variation of heat shock protein gene expression in the brain of cold-induced pulmonary hypertensive chickens. British Poultry Science 57(5): 636-642, 2016

Gene expression of endothelin-1 and its receptors in the heart of broiler chickens with T(3)-induced pulmonary hypertension. Research in Veterinary Science 91(3): 370-375, 2012

Oxidant and non-enzymatic antioxidant status in measles. Journal of Tropical Pediatrics 53(2): 83-86, 2006

Cardiac renin-angiotensin system (gene expression) and plasma angiotensin II in chickens with T3-induced pulmonary hypertension. British Poultry Science 57(4): 444-450, 2016

Pro-oxidant activity of aluminum in the rat hippocampus: gene expression of antioxidant enzymes after melatonin administration. Free Radical Biology & Medicine 38(1): 104-111, 2004

Expression of PKC alpha in pulmonary arterioles and its association with pulmonary vascular remodeling in broilers with pulmonary hypertension induced by cold temperature exposure. Scientia Agricultura Sinica 38(9): 1917-1922, 2005

Modulatory effect of Ganoderma lucidum on expression of xenobiotic enzymes, oxidant-antioxidant and hormonal status in 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats. Pharmacognosy Magazine 9(34): 167-175, 2013

The antioxidant status of photosynthesizing leaves under nutrient deficiency: redox regulation, gene expression and antioxidant activity in Arabidopsis thaliana. Physiologia Plantarum 120(1): 63-73, 2004

Evaluation of endothelial and inducible nitric oxide synthase mRNA expression in the lung of broiler chickens with developmental pulmonary hypertension due to cold stress. British Poultry Science 47(2): 223-229, 2006

Effect of L-arginine on activity of NOS in pulmonary arterioles in broilers with pulmonary hypertension induced by cold temperature. Journal of Nanjing Agricultural University 28(3): 79-82, 2005

Altered oxidant-antioxidant status in non-obese men with moderate essential hypertension. Indian Journal of Medical Sciences 61(6): 326-331, 2007

Expression of PDGF-beta receptor in broilers with pulmonary hypertension induced by cold temperature and its association with pulmonary vascular remodeling. Research in Veterinary Science 88(1): 116-121, 2010

Oxidant-antioxidant status and pulmonary function in welding workers. Journal of Occupational Health 47(4): 286-292, 2005

Differential gene expression of three nitric oxide synthases is consistent with increased nitric oxide in the hindbrain of broilers with cold-induced pulmonary hypertension. British Poultry Science 56(4): 436-442, 2016