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Oxidant stress promotes disease by activating CaMKII

Oxidant stress promotes disease by activating CaMKII

Journal of Molecular and Cellular Cardiology 89(Pt B): 160-167

CaMKII is activated by oxidation of methionine residues residing in the regulatory domain. Oxidized CaMKII (ox-CaMKII) is now thought to participate in cardiovascular and pulmonary diseases and cancer. This invited review summarizes current evidence for the role of ox-CaMKII in disease, considers critical knowledge gaps and suggests new areas for inquiry.

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Accession: 058488153

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PMID: 26475411

DOI: 10.1016/j.yjmcc.2015.10.014

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