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Oxidation of cholesterol and O-protected derivatives by the environmental pollutant NO₂



Oxidation of cholesterol and O-protected derivatives by the environmental pollutant NO₂



Chemical Communications 52(21): 4060-4063



Exposure of O-protected and free cholesterol to NO2˙ under exclusion of water leads to nitroimine nitrates through a non-radical mechanism, which reveals the high susceptibility of the π system to oxidative damage. In the presence of moisture the reaction leads to 6-nitrocholesterols , which result from hydrolysis and oxidation of 2.

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Accession: 058488285

Download citation: RISBibTeXText

PMID: 26892038

DOI: 10.1039/c5cc09663d


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