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Oxidation resistance 1 (OXR1) participates in silkworm defense against bacterial infection through the JNK pathway

Oxidation resistance 1 (OXR1) participates in silkworm defense against bacterial infection through the JNK pathway

Insect Science 24(1): 17-26

Bacterial infection causes enhanced reactive oxygen species (ROS) levels in insects. Oxidation resistance 1 (OXR1) plays an antioxidant role in eukaryotic organisms, including insects. In this report, we demonstrated that Pseudomonas aeruginosa and Staphylococcus aureus infection and hydrogen peroxide (H2 O2 ) injection induced the expression of specific transcriptional isoforms of OXR1 in larval silkworms. We further showed that a Jun kinase (JNK) pathway inhibitor, SP600125, down-regulated expression of OXR1 during infection, leading to elevated H2 O2 levels in the hemolymph, resulting in lower viability of the injected bacteria inside the silkworm larvae. Our study suggests that OXR1 participates in protecting larval silkworms from oxidative stress and bacterial infection through the JNK pathway.

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Accession: 058488344

Download citation: RISBibTeXText

PMID: 26507465

DOI: 10.1111/1744-7917.12285

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